{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:09:41Z","timestamp":1789204181637,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the real\u2010world clinical practice of estrogen and progestogen prescriptions for menopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a health care database in Japan, we conducted a cross\u2010sectional study on estrogen prescriptions and detailed analyses of newly initiated estrogens and concomitant prescriptions of progestogens. Data between January 2005 and December 2021 were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, the proportion of women aged 45\u201349\u2009years receiving estrogens was 25.8 [95% confidence interval (CI): 25.3, 26.3] per 1000 women, while it was 6.4 [95% CI: 6.0, 6.7] for those aged \u226560\u2009years. The prescription of estrogens gradually increased in women aged 50\u201359\u2009years after 2009. In women without a history of hysterectomy, transdermal estradiol was the primary form of estrogens prescribed for \u2265180\u2009days, in women aged &lt;60\u2009years. The proportion of transdermal estradiol gradually increased each year, whereas that of oral\u2010conjugated equine estrogens decreased. Among progestogen, the proportions of dydrogesterone and transdermal norethisterone acetate increased over time, while that of medroxyprogesterone acetate decreased. Approximately 30% of women prescribed estrogens for \u2265180\u2009days did not initiate progestogen concurrently. In women undergoing hysterectomy, progestogen was not initiated in &gt;90% of cases, and transdermal estradiol was prescribed in approximately 80% of cases in 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reviewed the prescription of estrogens in menopausal women in Japan. A considerable number of women with a uterus are receiving estrogen therapy rather than estrogen\u2010progestogen therapy (EPT), despite the guidelines recommending the use of EPT in these women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15795","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:29:19Z","timestamp":1695778159000},"page":"2952-2961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world practice of estrogen and progestogen prescriptions in menopausal women in Japan: A descriptive study using a Japanese claims database"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-5913","authenticated-orcid":false,"given":"Yoshihide","family":"Inayama","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto 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