{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:58:00Z","timestamp":1769065080429,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to report the treatment outcomes of radiation therapy for early\u2010stage endometrial cancer patients. In addition, this study intended to identify high\u2010risk factors that require pelvic radiotherapy (PRT) in addition to vaginal brachytherapy (VBT) for intermediate\u2010risk endometrial cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with early\u2010stage endometrial cancer receiving postoperative VBT alone or with PRT were included. Propensity score matching was used to balance the two study groups. The primary endpoint was locoregional recurrence (LRR). Age\u2010adjusted Charlson comorbidity index and substantial lymphovascular space invasion were selected for subgroup analyses to identify the benefits of PRT over VBT alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2005 to 2017, a total of 288 patients underwent analysis following propensity score matching. Of these, 144 received VBT and 144 received PRT. There was no significant difference in 5\u2010year LRR between VBT and PRT for both intermediate (0% vs. 0%) and high\u2010intermediate risk patients (3.5% VBT vs. 5.4% PRT; HR 0.54: 0.05\u20136.00; <jats:italic>p<\/jats:italic>\u2009=\u20090.616). The subgroup analyses revealed no significant factors favoring PRT over VBT. Patients with high comorbidities may have higher risks of non\u2010cancer death after receiving PRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative VBT alone is sufficient for early\u2010stage intermediate\u2010risk endometrial cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15800","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:31:19Z","timestamp":1696318279000},"page":"2918-2928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment outcomes of early\u2010stage endometrial cancer patients: A propensity score matching of vaginal brachytherapy versus pelvic radiotherapy"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-4899","authenticated-orcid":false,"given":"Janjira","family":"Petsuksiri","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department 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