{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:42:20Z","timestamp":1783114940894,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Gynecologic cancer chemotherapy impacts the quality of life (QOL) of patients, with lasting adverse events that may require treatment adjustments or discontinuation. Consequently, real\u2010time symptom monitoring before outpatient visits has resulted in improved QOL for patients and extended survival times. This study investigated whether there are differences between electronic patient\u2010reported outcomes (e\u2010PRO\u2010CTCAE) and physician\u2010assessed outcomes (NCI\u2010CTCAE) evaluated in an outpatient setting in gynecologic cancer chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted on 50 patients who received their first chemotherapy treatment at St. Marianna University Hospital Obstetrics and Gynecology from July 1, 2021 to December 31, 2022. PRO\u2010CTCAE and NCI\u2010CTCAE were evaluated at each instance of chemotherapy and 2\u2009weeks after. The PRO\u2010CTCAE was additionally collected weekly using e\u2010PRO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The values for \u201cJoint Pain,\u201d \u201cNausea,\u201d \u201cTaste Disturbance,\u201d \u201cConstipation,\u201d \u201cInsomnia,\u201d \u201cFatigue,\u201d \u201cLimb Edema,\u201d and \u201cConcentration Impairment\u201d were consistently higher in PRO\u2010CTCAE than in NCI\u2010CTCAE, indicating that physicians underestimated the severity of adverse events. In contrast, there was no significant difference in \u201cPeripheral Neuropathy,\u201d demonstrating that physicians had a good understanding of this condition in patients. The weekly responses obtained from e\u2010PRO revealed that symptom exacerbations peaked outside of clinic visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated physicians tend to underestimate most adverse events. Moreover, the responses using e\u2010PRO revealed peak symptom deterioration occurred outside of outpatient visits. This suggested that e\u2010PRO and actions taken in response to them can improve patients' QOL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15811","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:19:24Z","timestamp":1697671164000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prospective analysis of patient\u2010reported outcomes and physician\u2010reported outcomes with gynecologic cancer chemotherapy"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3432-6348","authenticated-orcid":false,"given":"Tomo","family":"Takenaga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Marianna University School of Medicine  Kawasaki 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