{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:36:34Z","timestamp":1747186594412,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Both morbidity and mortality rates of cervical cancer are increasing, especially in reproductive\u2010aged women. Radical trachelectomy (RT) is an effective fertility\u2010preserving surgery for early\u2010stage cervical cancer. This study aimed to determine the influence of RT on endometrial thickness during in vitro fertilization\u2010embryo transfer (IVF\u2010ET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four patients had undergone RT, and 23 women undergoing IVF\u2010ET treatment (105 ET cycles) were included. Endometrial thickness during hormone replacement therapy (HRT) was retrospectively evaluated and compared between patients with and without RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients (50 ET cycles) in the RT group and 12 (52 ET cycles) in the control group were investigated. Compared with the control group, higher ET cancellation rates were observed in patients in the RT group (1 of 52\u2009cycles [control group] vs. 8 of 50\u2009cycles [RT group], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Endometrial thinning was not affected by patient age at first IVF\u2010ET treatment, history of artificial abortion, preservation of uterine arteries during RT, or postoperative chemotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.27, 1, 1, and 1, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data revealed that RT influenced endometrial thickness in IVF\u2010ET. This was not affected by the background of the patients or perioperative management in this study. We could not reveal the underlying mechanism, but it is postulated that the transient postoperative uterine blood flow status and postoperative infections may have some effect on the endometrium. To resolve these issues, accumulation of evidences are required. We recommend informing patients about the impact of RT on IVF\u2010ET before starting assisted reproductive technology (ART).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15841","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:08:22Z","timestamp":1700870902000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The influence of radical trachelectomy on endometrial thickness in in vitro fertilization\u2010embryo transfer"],"prefix":"10.1111","volume":"50","author":[{"given":"Atsushi","family":"Yabuki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya 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University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Osuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-1825","authenticated-orcid":false,"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya 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