{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:40:30Z","timestamp":1784734830416,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the association between a history of recurrent spontaneous abortion (RSA) and adverse outcomes in women with spontaneous conception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search strategy from the inception to March 3, 2023 was run in PubMed, Embase, Cochrane Library, and Web of Science databases. The odds ratio (OR), and the 95% confidence interval (CI) or point estimation were used as the evaluation indexes. Each outcome measure tested was assessed for heterogeneity using the Cochran Q test. Sensitivity analyses were performed to test the credibility of the meta\u2010analysis results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies involving 1\u2009475\u2009389 pregnant women were included. A history of RSA was associated with gestational diabetes (OR: 2.21, 95% CI: 1.70\u20132.87, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), preeclampsia (OR: 2.06, 95% CI: 1.49\u20132.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), placenta previa (OR: 1.82, 95% CI: 1.09\u20133.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.021), placental abruption (OR: 1.67, 95% CI: 1.36\u20132.06, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), miscarriage (OR: 6.37, 95% CI: 3.83\u201310.57, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), preterm birth (OR: 1.80, 95% CI: 1.36\u20132.37, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), cesarean section (OR: 1.47, 95% CI: (1.13\u20131.91, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), perinatal death (OR: 2.24, 95% CI: 1.39\u20133.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and neonatal intensive care unit admission (OR: 1.39, 95% CI: 1.01\u20131.92, <jats:italic>p<\/jats:italic>\u2009=\u20090.047). However, the associations of a history of RSA with gestational hypertension, small for gestational age, fetal anomalies, fetal growth restriction, and postpartum hemorrhage were not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis indicates a history of RSA was associated with increased risks of several adverse outcomes in pregnant women with spontaneous conception.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15848","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T04:30:30Z","timestamp":1702269030000},"page":"281-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adverse outcomes in subsequent pregnancies in women with history of recurrent spontaneous abortion: A meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Dan","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Gynecology Suzhou Hospital of Traditional Chinese Medicine  Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengdan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology Suzhou Hospital of Traditional Chinese Medicine  Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gynecology Qingdao Women's and Children's Hospital  Qingdao Shandong Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Suzhou Hospital of Traditional Chinese Medicine  Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology Suzhou Hospital of Traditional Chinese Medicine  Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6588-3737","authenticated-orcid":false,"given":"Qingxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gynecology Suzhou Hospital of Traditional Chinese Medicine  Suzhou Jiangsu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab705"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00682-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"key":"e_1_2_9_6_1","volume-title":"The investigation and treatment of couples with recurrent first\u2010trimester and second\u2010trimester miscarriage","author":"Gynaecologists RCoOa","year":"2011"},{"key":"e_1_2_9_7_1","article-title":"Leveraging electronic health records to identify risk factors for recurrent pregnancy loss across two medical centers: a case\u2010control study","author":"Roger J","year":"2023","journal-title":"Res Sq"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13414"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03398-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S264229"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13248"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12348"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713650"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-023-03305-w"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.12.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-207"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01030.x"},{"issue":"12","key":"e_1_2_9_21_1","first-page":"957","article-title":"Specification for clinical diagnosis and management of placental abruption (1st edition)","volume":"47","author":"Obstetrics Group OAGB","year":"2012","journal-title":"J Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_9_22_1","unstructured":"Gynaecologists RCoOa.Placenta Praevia Placenta Praevia Accreta and Vasa Praevia: Diagnosis and Management. Green\u2010top Guideline No 27. pp. 1\u201326.2011."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13195"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.889"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-1930-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004251"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2016.1142214"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16458"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1759637"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.02.015"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2018.1475754"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.923394"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00987-2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.1.102"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.06.015"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13607"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092833"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4359424"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05053-8"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05154-z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03578-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz112"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202612199"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.01.041"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1598-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.10.6.414.419"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.3.175.190"},{"key":"e_1_2_9_49_1","first-page":"104","article-title":"Role of obesity in gestational hypertension in primigravidae women: a case control study in Shadegan, Iran","volume":"32","author":"Moftakhar L","year":"2018","journal-title":"Med J Islam Repub Iran"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04027-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13276"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2011-0315"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00599.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13072"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T04:50:19Z","timestamp":1721796619000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,10]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jog.15848"],"URL":"https:\/\/doi.org\/10.1111\/jog.15848","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,10]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}