{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:21:48Z","timestamp":1785363708886,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Listeriosis is caused by the bacterium, <jats:italic>Listeria monocytogenes<\/jats:italic>, and is a significant health concern because of high hospitalization and mortality rates. This study reports seven cases of pregnancy\u2010associated listeriosis diagnosed with matrix\u2010assisted laser desorption ionization\u2010time of flight (MALDI\u2010TOF) mass spectrometry performed on infection\u2010positive blood culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood culture\u2010positive samples of seven patients whose pregnancy was complicated by <jats:italic>Listeria<\/jats:italic> infection and treated at Xuanwu Hospital of Capital Medical University between January 2016 and December 2021 were analyzed retrospectively. Strains identified by MALDI\u2010TOF mass spectrometry were compared with colony identification results. Identification accuracy and consistency were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of seven strains of <jats:italic>Listeria<\/jats:italic> were collected from seven pregnant women presented with fever (37.6\u201339.9\u00b0C). Clinical abnormalities included abnormal liver function, emaciation, hypoalbuminemia, hypocalcemia, hypokalemia, hyponatremia, ketosis, mild to moderate anemia, leukopenia, and thrombocytopenia. Compared with the traditional culture method, MALDI\u2010TOF mass spectrometry led to much earlier identification (4\u20136\u2009h vs. 3\u20134\u2009days) with 100% identification accuracy. Of the seven pregnancies complicated by <jats:italic>Listeria<\/jats:italic>, only two led to live births. Of the five fetal deaths, three occurred in the second trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this series of pregnancy\u2010associated listeriosis cases, the fetal mortality rate was 71%. MALDI\u2010TOF mass spectrometry is a valuable method that can identify <jats:italic>Listeria<\/jats:italic> from blood culture rapidly and accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15859","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:48:54Z","timestamp":1702442934000},"page":"508-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical significance of rapid detection and diagnosis of <i>Listeria<\/i> infection in blood with mass spectrometry"],"prefix":"10.1111","volume":"50","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyan","family":"Duan","sequence":"additional","affiliation":[{"name":"Education Section Xuanwu Hospital of Capital Medical University 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