{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:26:04Z","timestamp":1782332764779,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Endometriosis is a serious health problem among women of reproductive age, with pelvic pain and infertility. Given the limited success of current treatments, this study explores Neroli oil (N.O.) effects on inflammation, oxidation, angiogenesis, and tissue remodeling implicated in endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Albino Wistar female rats were used to simulate an endometriosis model. Groups were established for comparison: a control, an endometriosis model, a N.O.\u2010treated group, and a N.O.\u2010treated group postendometriosis induction. The study focused on Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), Interleukin 6, Interleukin 8, vascular endothelial growth factor (VEGF), myeloperoxidase, Matrix metalloproteinase\u20101 (MMP\u20101), nitric oxide, superoxide dismutase, catalase, and anti\u2010mullerian hormone values, as well as histopathological evaluations of endometriotic foci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AMH values showed a significant increase in the endometriosis group treated with N.O. compared with the endometriosis group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090,01).A statistically significant decrease was found in MMP\u20101 level in the endometriosis group that underwent N.O. (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Increased CAT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and decrease in nitric oxide (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) are found in N.O.\u2010treated endometriosis group. TNF\u2010\u03b1 levels in the endometriosis group showed a statistically significant increase in the endometriosis group when compared with the control and sham group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 respectively). In our study, a statistically significant increase was observed in VEGF levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in endometriosis group and significant decrease in the N.O. administered endometriosis model group. Groups treated with N.O. showed decreased inflammation and congestion scores. Histopathological assessments demonstrated reduced inflammation and tissue remodeling signs in endometriotic foci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the potential of N.O. in the treatment of endometriosis, owing to its anti\u2010inflammatory, antioxidant, and antiangiogenic properties that can disrupt chronic processes. Our findings lend support to utilization of herbal remedies for the management of endometriosis, thereby emphasizing the necessity for additional comprehensive investigations in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15866","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:55:06Z","timestamp":1703638506000},"page":"516-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti\u2010inflammatory, antioxidant, antiangiogenic, and therapeutic efficacy of neroli oil in rats with endometriotic lesions"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-2764","authenticated-orcid":false,"given":"Mujde","family":"Canday","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Kafkas University  Kars 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