{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:27:38Z","timestamp":1759991258307,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Some studies have suggested that cesarean section diverticulum may affect the pregnancy outcomes of assisted reproductive technology through a variety of mechanisms. This study aims to explore whether previous cesarean section and uterine scar diverticulum affect pregnancy outcomes after in vitro fertilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 954 infertile women with only one previous delivery who had in vitro fertilization treatment and underwent fresh embryo transplantation for the first time at our center between 2015 and 2019. We first divided the women into two groups by previous vaginal delivery (<jats:italic>n<\/jats:italic>\u2009=\u2009557) or cesarean section delivery (<jats:italic>n<\/jats:italic>\u2009=\u2009397), and the latter group included 88 women with cesarean diverticulum and 309 women without cesarean diverticulum. Baseline characteristics were compared and analyzed, and logistic regression analyses were performed to explore the different pregnancy outcomes among the above groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although the live birth rate, clinical pregnancy rate, and mean embryo implantation rate after in vitro fertilization were significantly reduced in patients with previous cesarean section (live birth rate: 26.45% vs. 43.99%, adjusted OR: 0.602, CI: 0.447\u20130.810; clinical pregnancy rate: 35.26% vs. 49.91%, adjusted OR: 0.724, CI: 0.544\u20130.962; mean embryo implantation rate: 0.227\u2009\u00b1\u20090.378 vs. 0.243\u2009\u00b1\u20090.397, adjusted OR: 0.860, CI: 0.514\u20131.439), there were no significant differences in pregnancy outcomes between the women with cesarean diverticulum and without cesarean diverticulum (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) or between the two groups at different ages. The live birth and clinical pregnancy rates in the women with residual muscle thickness \u22642.2\u2009mm or prolonged menstruation were reduced, but the difference was not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed reduced pregnancy and live birth rates after in vitro fertilization in patients with previous cesarean section, while uterine scarring did not adversely affect pregnancy and delivery outcomes after in vitro fertiliazation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15884","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T06:23:43Z","timestamp":1704954223000},"page":"699-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reproductive outcomes after in vitro fertilization in women with cesarean section scar diverticulum: A retrospective study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-0001","authenticated-orcid":false,"given":"Qin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital School of Medicine Zhejiang University  Hangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital School of Medicine Zhejiang University  Hangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital School of Medicine Zhejiang University  Hangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-020-01370-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13199"},{"issue":"11","key":"e_1_2_8_5_1","article-title":"Hysteroscopy in the treatment of Myometrial scar defect (diverticulum) following cesarean section delivery: a systematic review and meta\u2010analysis","volume":"12","author":"Al Mutairi BH","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027531"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.31486\/toj.18.0048"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14822"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa094"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.5321"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26171"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det343"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Previous caesarean section is associated with lower subsequent in vitro fertilization live birth rates","volume":"25","author":"Tweel MM","year":"2019","journal-title":"Hum 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