{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:19:17Z","timestamp":1785737957328,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The main feature of adult granulosa cell tumors (AGCT) is their capacity to secrete hormones, with nearly all of them capable of synthesizing oestradiol. The primary goal of this study is to identify synchronized endometrial pathologies, particularly endometrial cancer, in AGCT patients who had undergone a hysterectomy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n The study cohort comprised retrospectively of 316 AGCT patients from 10 tertiary gynecological oncology centers. AGCT surgery consisted of bilateral salpingo\u2010oophorectomy, hysterectomy, peritoneal cytology, omentectomy, and the excision of any suspicious lesion. The median tumor size value was used to define the relationship between tumor size and endometrial cancer. The relationship between each value and endometrial cancer was evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Endometrial intraepithelial neoplasia, or hyperplasia with complex atypia, was detected in 7.3% of patients, and endometrial cancer in 3.1% of patients. Age, menopausal status, tumor size, International Federation of Gynecology and Obstetrics stage, ascites, and CA\u2010125 level were not statistically significant factors to predict endometrial cancer. There was no endometrial cancer under the age of 40, and 97.8% of women diagnosed with endometrial hyperplasia were over the age of 40. During the menopausal period, the endometrial cancer risk was 4.5%. Developing endometrial cancer increased to 12.1% from 3.2% when the size of the tumor was >150\u2009mm in menopausal patients (\n p<\/jats:italic>\n \u2009=\u20090.036).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Endometrial hyperplasia, or cancer, occurs in approximately 30% of AGCT patients. Patients diagnosed with AGCT, especially those older than 40\u2009years, should be evaluated for endometrial pathologies. There may be a relationship between tumor size and endometrial cancer, especially in menopausal patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.15896","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:19:52Z","timestamp":1706847592000},"page":"655-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Defining the relationship between ovarian adult granulosa cell tumors and synchronous endometrial pathology: Does ovarian tumor size correlate with endometrial cancer?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-2744","authenticated-orcid":false,"given":"Abdurrahman Alp","family":"Tokalioglu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-7886","authenticated-orcid":false,"given":"Okan","family":"Oktar","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-6479","authenticated-orcid":false,"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-9718","authenticated-orcid":false,"given":"Cagatayhan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Ankara University, Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-3560","authenticated-orcid":false,"given":"Ozgur","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine University of Health Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-9424","authenticated-orcid":false,"given":"Hande Esra Koca","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-4202","authenticated-orcid":false,"given":"Yesim","family":"Ucar","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-4883","authenticated-orcid":false,"given":"Fatih","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-062X","authenticated-orcid":false,"given":"Burak","family":"Ersak","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-3244","authenticated-orcid":false,"given":"Necim","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine University of Health Sciences Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4554","authenticated-orcid":false,"given":"Fatma","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine University of Health Sciences Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-7375","authenticated-orcid":false,"given":"Aysun","family":"Alci","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine University of Health Sciences Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-6470","authenticated-orcid":false,"given":"Sevda","family":"Bas","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine University of Health Sciences Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-8497","authenticated-orcid":false,"given":"Goksen","family":"Gorgulu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine University of Health Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-5722","authenticated-orcid":false,"given":"Ilker","family":"Selcuk","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-1075","authenticated-orcid":false,"given":"Gokhan","family":"Ucar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-9422","authenticated-orcid":false,"given":"Ozgur","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Hitit University, Faculty of Medicine Corum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-9104","authenticated-orcid":false,"given":"Caner","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-8068","authenticated-orcid":false,"given":"Cigdem","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Hitit University, Faculty of Medicine Corum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-4196","authenticated-orcid":false,"given":"Gunsu Kimyon","family":"Comert","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-4682","authenticated-orcid":false,"given":"Isin","family":"Ureyen","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine University of Health Sciences Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-6915","authenticated-orcid":false,"given":"Tayfun","family":"Toptas","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine University of Health Sciences Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9053","authenticated-orcid":false,"given":"Mehmet Ali","family":"Narin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine University of Health Sciences Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-4385","authenticated-orcid":false,"given":"Tolga","family":"Tasci","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Bahcesehir University, Faculty of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-2224","authenticated-orcid":false,"given":"Salih","family":"Taskin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Ankara University, Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-5551","authenticated-orcid":false,"given":"Nurettin","family":"Boran","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-688X","authenticated-orcid":false,"given":"Bulent","family":"Ozdal","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-4302","authenticated-orcid":false,"given":"Muzaffer","family":"Sanci","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine University of Health Sciences Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0929-3271","authenticated-orcid":false,"given":"Dogan","family":"Uncu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-6864","authenticated-orcid":false,"given":"Vakkas","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-3837","authenticated-orcid":false,"given":"Ozlem Moraloglu","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-3848","authenticated-orcid":false,"given":"Yaprak","family":"Ustun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-5760","authenticated-orcid":false,"given":"F\u0131rat","family":"Ortac","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Ankara University, Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-1143","authenticated-orcid":false,"given":"Taner","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-3952(22)04460-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735408322845"},{"key":"e_1_2_8_4_1","volume-title":"Williams gynecology","author":"Hoffman BL","year":"2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-340"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1343"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy001"},{"issue":"11","key":"e_1_2_8_8_1","article-title":"Adult\u2010type ovarian granulosa cell tumour: treatment outcomes from a single\u2010institution experience","volume":"14","author":"Alhusaini H","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.08.007"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"231","article-title":"Clinicopathologic review of 118 granulosa and 82 theca cell tumors","volume":"55","author":"Evans AT","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841868009130148"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(79)90090-8"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"48","article-title":"Hyperplastic processes and endometrial cancer in patients with hormone\u2010producing ovarian tumors","volume":"37","author":"Adamian R","year":"1991","journal-title":"Vopr Onkol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197501)35:1<231::AID-CNCR2820350128>3.0.CO;2-O"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.3.158"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000917"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182a57fb4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2011.22.3.188"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.12.016"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.02.032"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200508000-00050"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90083-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.020"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4135-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5042-x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.852127"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00969"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.021"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1294760"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:53:17Z","timestamp":1712105597000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jog.15896"],"URL":"https:\/\/doi.org\/10.1111\/jog.15896","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3029359\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-3029359\/v1","asserted-by":"object"}]},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"2023-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}