{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:34:15Z","timestamp":1777113255371,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Preeclampsia (PE) is a major maternal and fetal threat. Previous risk\u2010scoring methods in guidelines lacked precision. The Fetal Medicine Foundation (FMF) proposed a first\u2010trimester PE screening model using Bayes' theorem.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> Prediction Model<\/jats:title><jats:p>FMF prediction model combines maternal characteristics and medical\/obstetrical history to determine prior risk and further incorporate maternal blood pressure, maternal serum biomarkers, and uterine Doppler pulsatility index expressed as multiples of the median (MoM) to estimate posterior risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Low\u2010Dose Aspirin Prevention<\/jats:title><jats:p>Low\u2010dose aspirin is one of\u00a0the potential PE prevention strategies. Initiating it before 16\u2009weeks is crucial. Aspirin's antiplatelet and anti\u2010inflammatory properties align with PE's pathophysiology. Dosing and resistance warrant further study, but a standard regimen of 150\u2009mg nightly, starting before 16\u2009weeks, is widely supported.<\/jats:p><\/jats:sec><jats:sec><jats:title>PE Prevention in Practice<\/jats:title><jats:p>Clinical trials, including ASPRE, affirm aspirin's role in PE prevention. Starting aspirin based on FMF screening significantly reduces preterm PE and associated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Advancements and Prospects<\/jats:title><jats:p>Emerging research explores predictors like maternal ophthalmic arterial waveform. Regional variations, especially in Asian populations, are considered. Machine learning and AI show promise, but examiner expertise remains essential for accurate prediction.<\/jats:p><jats:p>In conclusion, integrating FMF's first\u2010trimester PE screening with low\u2010dose aspirin offers a promising strategy. 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