{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:24:57Z","timestamp":1767705897688,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the impact of letrozole cotreatment progestin\u2010primed ovarian stimulation (PPOS) (Le PPOS) in controlled ovarian stimulation (COS) and the pregnancy outcomes in frozen\u2013thawed embryo transfer cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included women who underwent in vitro fertilization (IVF)\/intracytoplasmic sperm injection (ICSI). A total of 2575\u2009cycles were included (1675 in the Le PPOS group and 900 in the PPOS group). The primary outcome was the clinical pregnancy rates. The secondary outcome was the live birth rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, propensity score matching (PSM) was performed to create a perfect match of 379 patients in each group. After matching, the numbers of oocytes retrieved, mature oocytes, fertilization, and clinical pregnancy rates were more favorable in the Le PPOS group than in the PPOS group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The multivariable analysis showed that the clinical pregnancy rate was higher in the Le PPOS than in the PPOS group (odds ratio\u2009=\u20091.46, 95% confidence interval: 1.05\u20132.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) after adjusting for potentially confounding factors (age, anti\u2010M\u00fcllerian hormone levels, antral follicular count, the type of embryo transferred, number of transferred embryos, body mass index, and follicular stimulating hormone and estradiol levels on starting day).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This retrospective study with a limited sample size suggests that the Le PPOS protocol might be an alternative to the PPOS protocol in women undergoing COS and could lead to better pregnancy outcomes. The results should be confirmed using a formal randomized controlled trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15911","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T02:23:31Z","timestamp":1708914211000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Letrozole cotreatment progestin\u2010primed ovarian stimulation in women undergoing controlled ovarian stimulation for in vitro fertilization"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-5635","authenticated-orcid":false,"given":"Xiaoning","family":"Wang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine  Shiyan People's Republic of China"},{"name":"Hubei Clinical Research Center for Reproductive Medicine  Shiyan People's Republic of China"},{"name":"Biomedical Engineering College, Hubei 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