{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:14:58Z","timestamp":1777947298358,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To investigate the effects of levothyroxine and prednisolone treatment, or in combination, on positive thyroid autoantibodies in infertile patients undergoing in vitro fertilization (IVF) therapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective study included a total of 190 patients with positive thyroid autoantibodies (anti\u2010T and anti\u2010TPO) who underwent IVF treatment between January 2008 and March 2016. Patients were divided into four groups: group 1\u2014levothyroxine group (\n n<\/jats:italic>\n \u2009=\u200950), group 2\u2013prednisolone group (\n n<\/jats:italic>\n \u2009=\u200950), group 3\u2013levothyroxine and prednisolone combination (\n n<\/jats:italic>\n \u2009=\u200925), group 4\u2014control group (\n n<\/jats:italic>\n \u2009=\u200965). Anti\u2010T and anti\u2010TPO levels before IVF and at the time of embryo transfer (ET), b\u2010hcg positivity, clinical and biochemical pregnancy, miscarriage rate, and live birth rate were compared among groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In levothyroxine\u2010treated group, mean anti\u2010TPO levels significantly decreased at the time of ET compared to before IVF treatment levels (\n p<\/jats:italic>\n \u2009=\u20090.036). In group 3, mean anti\u2010T and anti\u2010TPO levels significantly decreased at the time of ET compared to levels before IVF treatment (\n p<\/jats:italic>\n \u2009<\u20090.05). Patients who became pregnant in group 1, mean anti\u2010T anti\u2010TPO levels significantly decreased compared to before IVF treatment levels (\n p<\/jats:italic>\n \u2009<\u20090.05). The biochemical pregnancy rate was significantly higher in group 2 (\n p<\/jats:italic>\n \u2009=\u20090.03). Abortion rates were the highest in group 3, but no significant difference was found among groups. The group treated with levothyroxine had a significantly increased rate of live birth compared to the control group (\n p<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Levothyroxine addition during IVF treatment of patients with positive thyroid antibodies in subclinical hypothyroidism increases the take\u2010home baby pregnancy rate. Whether subclinical hypothyroidism or not in IVF treatment, levothyroxine is more effective than low\u2010dose corticosteroids.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.15926","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:59:15Z","timestamp":1710572355000},"page":"941-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of levothyroxine and prednisolone treatment on pregnancy in in vitro fertilization patients with positive thyroid autoantibodies"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-1075","authenticated-orcid":false,"given":"Zahid","family":"Agaoglu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ministry of Health, Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munire Funda","family":"Cevher Akdulum","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Ozturk Agaoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ministry of Health, Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konul","family":"Mursel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Akay Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep Onur","family":"Karabacak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Gazi University Ankara 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