{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:15Z","timestamp":1787015595397,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Sertoli\u2013Leydig cell tumors (SLCTs) are rare neoplasms occurring in young women with 60% associated with\n                      <jats:italic>DICER1<\/jats:italic>\n                      mutations. This is only the second published case series of patients with SLCTs with associated\n                      <jats:italic>DICER1<\/jats:italic>\n                      gene alterations.\n                      <jats:italic>DICER1<\/jats:italic>\n                      syndrome is a rare inherited tumor\u2010susceptibility syndrome affecting organs such as the ovaries. We use this case series to inform readers on this increasingly important condition in gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We present three young females presenting with secondary amenorrhoea, hirsutism, acne and in one case tonic\u2013clonic seizures. All cases had high testosterone levels and an adnexal mass on ultrasound. Following surgical removal, pathology confirmed SLCTs and genetic testing followed. All three patients had\n                      <jats:italic>DICER1<\/jats:italic>\n                      syndrome with two patients subsequently found to be related.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The prevalence of\n                      <jats:italic>DICER1<\/jats:italic>\n                      syndrome in the population is estimated to be 1 in 10\u2009000 with a spectrum of sex cord stromal tumors affecting young women. The associated pathological classifications and management. This paper describes the\n                      <jats:italic>DICER1<\/jats:italic>\n                      gene and the associated tumor predisposition syndrome alongside a surveillance protocol for use in clinical practice. It promotes discussion over the importance of early clinical genetics involvement in sex\u2010cord stromal tumors and the associated difficulties in counseling in a young patient population. Genetic testing and early detection are imperative for targeted surveillance of at\u2010risk organs to be performed but despite this there is no international guidance. The cases highlight the psychological impact of tumors in young patients and provokes an ethical discussion over\n                      <jats:italic>DICER1<\/jats:italic>\n                      gene's inclusion in preimplantation genetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>DICER1<\/jats:italic>\n                      syndrome is a rare but increasingly important condition in pediatric and adolescent gynecology with a paucity of published data and case reports. This makes international consensus on management and surveillance difficult.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15939","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T20:28:51Z","timestamp":1712780931000},"page":"1132-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Sertoli\u2013Leydig<\/scp>\n                    tumor and\n                    <scp>DICER1<\/scp>\n                    gene mutation: A case series and literature review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-4378","authenticated-orcid":false,"given":"Andrew A","family":"Durden","sequence":"first","affiliation":[{"name":"Department of Gynaecology Oncology St Michael's Hospital, University Hospital Bristol and Weston NHS Trust  Bristol 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