{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:11:32Z","timestamp":1788786692180,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Setting<\/jats:title>\n Previous studies addressed the association between anti\u2010thyroid antibodies and recurrent miscarriage (RM), however, the role of anti\u2010thyroid antibodies in RM patients is debatable.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n Therefore, we conducted this meta\u2010analysis and the aim of this current study was to assess whether anti\u2010thyroid peroxidase (anti\u2010TPO) and\/or anti\u2010thyroglobulin (anti\u2010TG) antibody positivity was associated with RM.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A meta\u2010analysis was conducted.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Recurrent miscarriage patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n STATA 12.0 software were applied to compute odds ratios (ORs)\/relative risks (RRs) and 95% CIs regarding association between anti\u2010TPO and anti\u2010TG antibodies and the prevalence of RM.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n N<\/jats:italic>\n \u2009=\u200928 studies (8875 participants) explored effect of anti\u2010thyroid antibodies on RM. Analysis of the 28 studies revealed significant association between anti\u2010TPO, anti\u2010TG antibodies and the prevalence of RM with a random effects model (OR\/RR\u2009=\u20092.02; 95% CI: 1.63\u20132.51,\n p<\/jats:italic>\n \u2009<\u20090.001;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200944.3%,\n p<\/jats:italic>\n value for\n Q<\/jats:italic>\n test\u2009=\u20090.004). Analysis of the 20 studies revealed significant association between anti\u2010TPO antibodies and the prevalence of RM with a random effects model (OR\/RR\u2009=\u20091.59; 95% CI: 1.25\u20132.03,\n p<\/jats:italic>\n \u2009<\u20090.001;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200943.1%,\n p<\/jats:italic>\n value for\n Q<\/jats:italic>\n test\u2009=\u20090.022). Analysis of the 14 studies revealed significant association between anti\u2010TG antibodies and the prevalence of RM with a random effects model (OR\/RR\u2009=\u20092.25; 95% CI: 1.56\u20133.23,\n p<\/jats:italic>\n \u2009<\u20090.001;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200949.2%,\n p<\/jats:italic>\n value for\n Q<\/jats:italic>\n test\u2009=\u20090.019).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Based on the currently available analysis, our findings suggest that women with anti\u2010TPO and\/or anti\u2010TG antibodies have a higher risk of RM than that in negative antibody women. Further investigation is needed to better clarify the exact role of the anti\u2010thyroid antibodies in RM and whether treatment is of benefit.<\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n First, differences from various detection methods and reagents used in different studies may affect the diagnostic interpretation of anti\u2010thyroid antibodies, which might influence the accuracy of this meta\u2010analysis. Second, positive anti\u2010thyroid antibodies seem likely to be part of a more general disorder of maternal immune system, due to restrictions of funding and condition, a complete autoantibody screening investigation is hardly to conduct in all participants, and this could be a possible limitation of all included studies. Third, there is no mention of thyroxine therapy on RM, making the meta\u2010analysis even more limited.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.15944","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T18:56:45Z","timestamp":1713121005000},"page":"1095-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of anti\u2010thyroid antibodies on recurrent miscarriage: A meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Hongyan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"},{"name":"The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidongzi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8638-7962","authenticated-orcid":false,"given":"Aiwu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou China"},{"name":"The First Clinical Medical College 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