{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:50:29Z","timestamp":1773211829187,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In this study, we aimed to investigate patient characteristics, efficacy, prognostic factors, and safety of olaparib maintenance therapy for platinum\u2010sensitive recurrent ovarian cancer at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients responding to platinum\u2010based therapy and starting olaparib maintenance therapy for recurrent epithelial ovarian, fallopian tube, or peritoneal cancer at Kurume University Hospital between January 2018 and November 2021 were enrolled in the study. Their data were extracted retrospectively from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 50 patients were included. The median (range) age of the patients, follow\u2010up time, and duration of olaparib maintenance therapy were 62 (39\u201387) years, 21.6 (2.2\u201345.9) months, and 7.2 (2\u201345.9) months, respectively. Among the 29 patients tested for homologous recombination (HR) status, 22 (75.9%) were positive for HR deficiency (HRD), 12 (54.5%) of whom had\n                      <jats:italic>BRCA<\/jats:italic>\n                      \u2010positive tumors. The median progression\u2010free survival was 8.9\u2009months (95% confidence interval: 6.2\u201312.6), and the median overall survival was 27.1\u2009months (95% confidence interval: 22.5\u201340.3). Multivariate analysis of prognostic factors revealed that HRD was an independent prognostic factor for both progression\u2010free survival and overall survival. The most common adverse event was nausea (any grade,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930, 60%), resulting in drug interruption (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923, 46%), dose reduction (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917, 34%), and discontinuation of treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091, 2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Olaparib maintenance therapy for recurrent platinum\u2010sensitive ovarian cancer at our institution was effective, with acceptable adverse events. HRD was the most significant prognostic factor for patients with recurrent platinum\u2010sensitive ovarian cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15965","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T07:28:25Z","timestamp":1715671705000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Olaparib maintenance therapy for platinum\u2010sensitive relapsed ovarian cancer at a single institution: A retrospective study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-5599","authenticated-orcid":false,"given":"Takahiro","family":"Katsuda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-630X","authenticated-orcid":false,"given":"Shin","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongmyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimio","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","unstructured":"Cancer Registry and Statistics.Cancer Information Service National Cancer Center Japan (Vital Statistics of Japan). 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