{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:05Z","timestamp":1791925385855,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sulfotransferase family 2B member 1 (SULT2B1) has been reported to play oncogenic role in many types of cancers. Nevertheless, the role that SULT2B1 played in ovarian cancer (OC) and the hidden molecular mechanism is obscure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Expression of SULT2B1 in OC was analyzed by GEPIA database. qRT\u2010PCR and western blot (WB) was applied for the appraisement of SULT2B1 and Annexin A9 (ANXA9) in OC cell lines. The capabilities of cells to proliferate, migrate and invade were assessed with CCK\u20108 assay, wound healing assay, along with transwell assay. Cell apoptotic level was estimated utilizing flow cytometry. WB was employed for the evaluation of migration\u2010 and apoptosis\u2010related proteins. Bioinformatic analysis and co\u2010immunoprecipitation were used to predict and verify the combination of SULT2B1 and ANXA9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data showed that SULT2B1 and ANXA9 were upregulated in OC cells. SULT2B1 depletion suppressed the proliferative, migrative, and invasive capabilities of SKOV3 cells but facilitated the cell apoptosis. SULT2B1\u2010regulated ANXA9 expression and were proved to bind to ANXA9. Additionally, ANXA9 deficiency exhibited the same impacts on cell migrative, invasive capability and apoptotic level as SULT2B1 silencing. Moreover, ANXA9 overexpression reversed the inhibitory impacts of SULT2B1 silencing on the proliferative, migrative, invasive, and apoptotic capabilities of SKOV3 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, SULT2B1 silencing repressed OC progression by targeting ANXA9.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15969","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T23:32:22Z","timestamp":1716420742000},"page":"1334-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Knockdown of sulfotransferase 2B1 suppresses cell migration, invasion and promotes apoptosis in ovarian carcinoma cells via targeting annexin A9"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-8573","authenticated-orcid":false,"given":"Haocheng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Gynecology, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University  Haikou Hainan Province P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University  Haikou Hainan Province P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqiu","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University  Haikou Hainan Province P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"561","article-title":"Ovarian cancer: an overview","volume":"91","author":"Penny SM","year":"2020","journal-title":"Radiol Technol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126532"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx443"},{"issue":"5","key":"e_1_2_10_7_1","first-page":"619","article-title":"New therapies for ovarian cancer","volume":"17","author":"O'Malley DM","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1956-8_1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2013.835609"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0277"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.05.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10211"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317719272"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010416"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443055"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060853"},{"issue":"4","key":"e_1_2_10_17_1","first-page":"206","article-title":"Annexins: involvement in cholesterol homeostasis, inflammatory response and atherosclerosis","volume":"33","author":"M\u00e9ndez\u2010Barbero N","year":"2021","journal-title":"Clin Investig Arterioscler"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150415"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.12605"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2021038527"},{"key":"e_1_2_10_21_1","article-title":"Hsa\u2010miR\u2010105\u20101 regulates cisplatin\u2010resistance in ovarian carcinoma cells by targeting ANXA9","volume":"2021","author":"Kou X","year":"2021","journal-title":"Anal Cell Pathol (Amst)"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21609"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2195-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1369"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.926780"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04174-w"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2477"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.01.034"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:02:32Z","timestamp":1722556952000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jog.15969"],"URL":"https:\/\/doi.org\/10.1111\/jog.15969","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"2024-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}