{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:09:23Z","timestamp":1776751763485,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance (IR), hyperuricemia (HUA), and recurrent pregnancy loss (RPL) elevate the risk of cardiovascular disease and metabolic disorders, while also impacting reproductive health. The relationship between IR, HUA, and RPL has not been thoroughly investigated. This study investigates the relationship between four IR surrogates and the risk of HUA in RPL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a real\u2010world study on RPL in China were analyzed using multivariable regression to determine the relationship between HUA and triglyceride and glucose (TyG) index, triglyceride glucose\u2010body mass index (TyG\u2010BMI), triglyceride to high\u2010density lipoprotein cholesterol (TG\/HDL\u2010c) ratio, and metabolic score for insulin resistance (METS\u2010IR). The predictive ability of these surrogates for detecting HUA in RPL patients was evaluated using the area under the curve and receiver operating characteristic analysis. Sensitivity analysis was performed using bootstrapping resampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 769 patients with a mean age of 30\u2009\u00b1\u20094\u2009years old, 8.32% of whom had HUA. Four IR surrogates were closely related to HUA in patients of RPL after adjusting for age, menstrual cycle, creatinine, alanine transaminase, aspartate transaminase, total cholesterol, homocysteine, and low\u2010density lipoprotein, with area under the curve values of TyG index (OR\u2009=\u20090.693, 95% confidence interval [CI]: 0.626, 0.759), TyG\u2010BMI (OR\u2009=\u20090.731 95% CI: 0.657, 0.805), TG\/HDL\u2010C (OR\u2009=\u20090.703, 95% CI: 0.641, 0.764), and METS\u2010IR (OR\u2009=\u20090.728, 95% CI: 0.655, 0.799). Bootstrap resampling yielded similar results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The TyG index, TyG\u2010BMI, TG\/HDL\u2010c, and METS\u2010IR significantly correlated with HUA in patients with RPL. The TyG\u2010BMI had the highest predictive value of the four IR surrogates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16061","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T03:16:01Z","timestamp":1727061361000},"page":"1873-1881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of the predictive value of four insulin resistance surrogates and hyperuricemia in women with recurrent pregnancy loss: A cross\u2010sectional study"],"prefix":"10.1111","volume":"50","author":[{"given":"Mei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Lanzhou University Second Hospital  Lanzhou China"},{"name":"Obstetrics and Gynaecology Intensive Care Unit Gansu Maternal and Child Health Hospital  Lanzhou 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