{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:53:42Z","timestamp":1773251622119,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to determine whether the effect of antenatal corticosteroids (ANS) differs in male and female fetuses without anomalies born before 32\u2009weeks in terms of mortality and short\u2010term morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study included infants born before 32\u2009weeks' gestation and admitted to the neonatal intensive care unit between January 1, 2018, and December 31, 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 210 infants with a median gestational age of 28.6\u2009weeks (24\u201331.6), a birth weight of 1065\u2009g (445\u20132165), and an ANS use rate of 80%. Compared to female fetuses exposed to ANS, male fetuses exposed to ANS had a lower mortality rate (23% and 11%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.038), but there were no differences in intraventricular hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, respiratory distress syndrome, and APGAR scores of 1st and 5th but an increased rate of bronchopulmonary dysplasia (moderate\/severe) (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). In addition, the mortality rate was similar in exposed and unexposed female fetuses (<jats:italic>p<\/jats:italic>\u2009=\u20090.850). Enzyme activities and steroid levels in the placenta might be different in male and female fetuses, which could explain the results of ANS administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, we have shown that ANS has no effect on mortality in female fetuses younger than 32\u2009weeks. Future studies may focus on adjusting the administration of ANS based on fetal sex, altering the dose or taking fetal sex into account when performing ANS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16062","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T04:23:30Z","timestamp":1724732610000},"page":"1830-1834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Should the sex of the fetus be considered when administering antenatal corticosteroids to preterm fetuses?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-0414","authenticated-orcid":false,"given":"Erdal","family":"\u015eeker","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Osmaniye State Hospital  Osmaniye Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvis","family":"Kraja","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maide Selin","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin Ezgi","family":"K\u00f6stek\u00e7i","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-4784","authenticated-orcid":false,"given":"Mehmet","family":"Obut","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gazi Yasargil Education and Training Hospital  Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Okulu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Erdeve","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Beg\u00fcm","family":"Atasay","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saadet","family":"Arsan","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Acar","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1578"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1268239"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.83.3.F182"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290065031"},{"issue":"3","key":"e_1_2_8_7_1","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"Roberts D","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Antenatal corticosteroids and the influence of sex on morbidity and mortality of preterm infants","volume":"35","author":"Ramos\u2010Navarro C","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1264"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1940941"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(07)80004-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.01.063"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00193.2017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.07.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00063"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.017218"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"Quinkler M Oelkers W Diederich S. 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