{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:21:04Z","timestamp":1775755264910,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Luteinizing hormone (LH) plays an important role in ovarian follicle maturation. Human menopausal gonadotropin (hMG) or low dose human chorionic gonadotropin (hCG) can provide LH supplementation during in vitro fertilization (IVF) ovarian stimulation, though studies directly comparing their impact on IVF outcomes are limited. The aim of the study was to determine whether LH supplementation with hMG versus low dose hCG during IVF stimulation affects live birth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fresh and frozen embryo transfers (ET) from 2017 to 2021 after standard long or antagonist protocols supplemented with hMG (75\u2013250\u2009IU) or low dose hCG (50\u2013100\u2009IU) during stimulation cycles in our academic center were included. Statistical analysis was performed with <jats:italic>T<\/jats:italic>\u2010tests, Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests, Chi\u2010square, and multiple linear and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and sixty eight unique stimulation cycles resulting in 213 fresh and 412 frozen embryo transfers were analyzed. There was a lower mature oocyte yield (10.9 vs. 11.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.044) but similar high\u2010quality blastocyst yield (3.6 vs. 3.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.11) for hMG vs low dose hCG. Live birth rates per transfer were comparable for fresh (42% vs. 49%, <jats:italic>p<\/jats:italic>\u2009=\u20090.24) and frozen (46% vs. 53%, <jats:italic>p<\/jats:italic>\u2009=\u20090.45) embryo transfers. Multiple logistic regressions showed no association between supplemental gonadotropin and live birth for both fresh and frozen embryo transfers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fresh and frozen IVF\u2010ET pregnancy outcomes were comparable after hMG versus low dose hCG supplementation, suggesting flexibility in supplemental LH dosing regimens that may address patient or physician preference or cost concerns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16065","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:04:46Z","timestamp":1725840286000},"page":"1935-1944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Luteinizing hormone supplementation with human menopausal gonadotropin versus low dose human chorionic gonadotropin during ovarian stimulation does not affect live birth rates after fresh and frozen embryo 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Flyckt","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"},{"name":"Division of Reproductive Endocrinology and Infertility University Hospitals Fertility Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Weinerman","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"},{"name":"Division of Reproductive Endocrinology and Infertility University Hospitals Fertility Center  Cleveland Ohio 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