{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:08Z","timestamp":1747186628970,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The importance of human papillomavirus (HPV) co\u2010testing using physician\u2010, self\u2010, and urine\u2010collected samples to predict cervical intraepithelial neoplasia (CIN) grade 1\u20132 prognoses has not been previously reported. Therefore, this study aimed to investigate outcomes of patients with CIN 1\u20132 who simultaneously underwent physician\u2010, self\u2010, and urine\u2010collection sampling tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted in Japan between October 2019 and November 2022 and examined the proportion of cases with CIN 1\u20132 progressions, the percentage of cases with persistent CIN 1\u20132, and the outcome differences according to the results of physician\u2010, self\u2010, and urine\u2010sampling tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 105 and 59 CIN 1 and 2 cases, respectively, with progression or persistence in 27 (29.3%) and 21 (50.0%) cases, respectively. The median follow\u2010up was 20 and 12\u2009months, respectively. Progression and persistence of CIN 1 were significantly associated with HPV\u2010positive physician\u2010 and self\u2010collected samples. No significant difference was observed between cases with CIN 2 who had HPV\u2010positive and HPV\u2010negative results using any sampling method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physician\u2010 and self\u2010testing for HPV are crucial for predicting disease progression risk in CIN 1 cases. Future research with an extended observation period and consideration of the progression risks is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16082","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T01:25:05Z","timestamp":1726104305000},"page":"1801-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human papillomavirus self\u2010sampling and urine\u2010sampling tests and the management and short\u2010term outcomes of cervical intraepithelial neoplasia: A prospective observational study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-6480","authenticated-orcid":false,"given":"Motoki","family":"Matsuura","sequence":"first","affiliation":[{"name":"Department of Gynecology Sapporo Medical University  Sapporo 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