{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:17:12Z","timestamp":1786371432806,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies provided inconsistent associations between diabetes mellitus (DM) and miscarriage, recurrent miscarriage (RM). Therefore, this study aims to evaluate the association between DM and miscarriage, specifically RM, through a meta\u2010analysis approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched for articles published before July 2023 in PubMed and Web of Science databases. STATA 12.0 software was used to compute all the results collected from included studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DM was associated with a higher risk of miscarriage, RM (miscarriage: odds ratio [OR]\/relative risk [RR]\u2009=\u20091.23, 95% confidence interval [CI] 1.13 to 1.34; RM: OR\/RR\u2009=\u20091.73, 95% CI 1.55 to 1.94). T1DM was associated with a higher risk of miscarriage (OR\/RR\u2009=\u20091.16, 95% CI 1.07 to 1.26). Similarly, T2DM showed a higher risk of miscarriage (OR\/RR\u2009=\u20091.44, 95% CI 1.23 to 1.68). Miscarriage, RM were associated with a higher risk of DM (miscarriage: OR\/RR\u2009=\u20091.14, 95% CI 1.08 to 1.19; RM: OR\/RR\u2009=\u20091.14, 95% CI 1.08 to 1.20). Furthermore, miscarriage was found to be associated with a higher risk of T2DM (OR\/RR\u2009=\u20091.08, 95% CI 1.05 to 1.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, our meta\u2010analysis findings indicate a significant association between DM and miscarriages as well as RM. As a result, women with a history of miscarriage should consider regular monitoring of their metabolic health as a potential benefit. Nevertheless, it is important to note that further research is needed to validate the results of our study and shed light on the biological mechanisms underlying these associations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16091","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T09:20:27Z","timestamp":1727169627000},"page":"2029-2037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between diabetes mellitus and miscarriage, recurrent miscarriage: A meta\u2010study"],"prefix":"10.1111","volume":"50","author":[{"given":"Suying","family":"Miao","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou Zhejiang Province China"},{"name":"Department of Obstetrics Zhejiang Provincial People's Hospital  Hangzhou Zhejiang Province 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