{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:34:57Z","timestamp":1761921297103,"version":"3.37.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To verify whether hemoglobin A1c (HbA1c) levels in early pregnancy can predict the diagnosis of gestational diabetes mellitus (GDM) in mid\u2010pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective cohort study of 2008 pregnant women who delivered singletons at the Yokohama City university Medical Center. Concomitant or history of diabetes mellitus and overt diabetes in pregnancy were excluded. Pregnant women at high risk for GDM underwent a one\u2010step 75\u2010g oral glucose tolerance test (OGTT) during mid\u2010pregnancy. For other pregnant women, GDM was diagnosed by a two\u2010step 75\u2010g oral glucose tolerance test (OGTT) when the 50\u2010g glucose challenge test result in mid\u2010pregnancy was \u2265140\u2009mg\/dL. The thresholds for 75\u2010g OGTT followed those of the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria (92\u2010180\u2010153\u2009mg\/dL). The relationship between HbA1c level measured at &lt;20\u2009weeks of gestation and GDM diagnosis at mid pregnancy was assessed using a receiver operating characteristic curve (ROC); area under the curve (AUC) and optimal cutoff value of HbA1c, predictive of GDM were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median HbA1c level at &lt;20\u2009weeks of gestation was 5.3%, and 8.5% of women were diagnosed with GDM. In the ROC curve of the GDM diagnosis rate by HbA1c level, AUC was 0.706, and the optimal cutoff value was 5.4%, with a sensitivity of 0.6176, specificity of 0.6834, positive predictive value of 15.4%, and negative predictive value of 95.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although HbA1c at less than 20\u2009weeks of gestation is acceptable discrimination as a diagnostic tool of GDM in mid\u2010pregnancy, it is not clinically useful to predict GDM in mid\u2010pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16108","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T04:48:59Z","timestamp":1728622139000},"page":"2211-2217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is early pregnancy hemoglobin A1c useful to predict gestational diabetes mellitus diagnosed during mid pregnancy?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-4340","authenticated-orcid":false,"given":"Sayuri","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Perinatal center for Maternity and Neonate Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Aoki","sequence":"additional","affiliation":[{"name":"Perinatal center for Maternity and Neonate Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-0911","authenticated-orcid":false,"given":"Noriyuki","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Yasuhi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Hospital Organization Nagasaki Medical Center  Omura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology International Catholic Hospital  Tokyo 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