{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:33:43Z","timestamp":1787319223784,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thin endometrium caused by various factors affects the conception rate of females worldwide; however, current medications are still insufficient. Therefore, a novel approach is needed. We previously reported the effect of menstrual blood\u2010derived mesenchymal stem cells (MenSCs) in ameliorating ethanol\u2010induced endometrial injuries. In the present study, we aimed to investigate whether the effect of MenSCs is enhanced by a combination of platelet\u2010rich plasma (PRP) infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An endometrial injury mouse model was established by infiltrating 95% ethanol for 15\u2009s into the uterus, followed by MenSCs, PRP, or MenSCs + PRP treatment. Pathological changes were observed by HE staining. The expression of CK18, vimentin, Itg\u03b1V\u03b23, and VEGF was determined using IHC staining and WB blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the model, MenSCs, PRP, and MenSCs + PRP treatments significantly improved endometrial damage and thickness, with the combined therapy displaying the most pronounced efficacy. The density of CK18\u2010, vimentin\u2010, and Itg\u03b1V\u03b23 positive cells increased most significantly in the MenSCs + PRP group of mice. In addition, the protein expression of CK18, vimentin, and VEGF was significantly upregulated after MenSCs + PRP, MenSCs, and PRP treatment, with MenSCs + PRP therapy showing the best efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MenSCs + PRP therapy is more beneficial for ameliorating ethanol\u2010induced endometrial damage than MenSCs or PRP alone, providing a basis for the investigation of novel approaches for treating thin endometria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.16135","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:38:42Z","timestamp":1730349522000},"page":"2338-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Menstrual blood\u2010derived mesenchymal stem cells combining with platelet\u2010rich plasma infusion in endometrium repair"],"prefix":"10.1111","volume":"50","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Xingtai People's Hospital  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Xingtai People's Hospital  Xingtai Hebei 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