{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:37:56Z","timestamp":1753879076735,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the correlation between serum luteinizing hormone (LH) levels preceding luteal replacement initiation and outcomes of frozen\u2013thawed embryo transfer (FET) cycles during hormone replacement therapy (HRT) without co\u2010administration of gonadotropin\u2010releasing hormone (GnRH) analog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 490 FET cycles performed between March 2018 and May 2023. Patients were categorized into quartiles based on their serum LH levels preceding luteal replacement. Multivariate logistic regression analysis was performed, with clinical pregnancy and live birth rates as dependent variables. The independent variables included women's mean age, serum LH, and estradiol levels preceding luteal replacement, and endometrial thickness during transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age, serum estradiol, and LH levels preceding luteal replacement were 36.8\u2009\u00b1\u20090.2\u2009years, 306.5\u2009\u00b1\u20097.7\u2009pg\/mL, and 10.3\u2009\u00b1\u20090.3\u2009mIU\/mL, respectively. The clinical pregnancy and live birth rates were 46.8% and 31.9%, respectively, and varied significantly between quartiles. Multivariate analysis revealed that younger age and higher LH levels were significantly associated with increased clinical pregnancy and live birth rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endogenous LH may facilitate pregnancy within FET cycles under HRT without GnRH analogs by preparing the endometrium for implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16176","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:15:15Z","timestamp":1733728515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical impact of endogenous luteinizing hormone in frozen\u2013thawed embryo transfer during hormone replacement cycle without gonadotropin\u2010releasing hormone analog coadministration: Effects on pregnancy outcomes"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-4939","authenticated-orcid":false,"given":"Akiko","family":"Sakata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-9690","authenticated-orcid":false,"given":"Shigeru","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-4063","authenticated-orcid":false,"given":"Yoshimitsu","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiko","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-2358","authenticated-orcid":false,"given":"Tomoko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1002\/rmb2.12494"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1007\/s10815-018-1248-8"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1095\/biolreprod.114.118562"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1007\/s10815-014-0273-5"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1016\/j.rbmo.2020.02.017"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1530\/RAF-21-0017"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.1210\/jc.80.5.1541"},{"key":"e_1_2_11_9_1","first-page":"3477","article-title":"Phase I study of CH\u2010003, single application study","volume":"12","author":"Nakamichi N","year":"1996","journal-title":"Clin Med"},{"volume-title":"Endotext","year":"2000","author":"Reed BG","key":"e_1_2_11_10_1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.1016\/j.fertnstert.2023.08.953"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1186\/s12958-021-00809-x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1186\/s12916-019-1354-1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1016\/j.brainres.2010.08.088"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1093\/humupd\/dmt030"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.1093\/humrep\/dew120"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_1","DOI":"10.1016\/j.rbmo.2020.03.009"},{"doi-asserted-by":"publisher","key":"e_1_2_11_18_1","DOI":"10.1093\/humrep\/dez079"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_1","DOI":"10.1016\/j.fertnstert.2020.10.039"},{"doi-asserted-by":"publisher","key":"e_1_2_11_20_1","DOI":"10.1093\/humrep\/13.10.2712"},{"issue":"10","key":"e_1_2_11_21_1","article-title":"Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction","volume":"10","author":"Craciunas L","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_1","DOI":"10.1016\/S1472-6483(10)61729-4"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_1","DOI":"10.1007\/s10815-013-0076-0"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T23:22:23Z","timestamp":1737588143000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,8]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jog.16176"],"URL":"https:\/\/doi.org\/10.1111\/jog.16176","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2024,12,8]]},"assertion":[{"value":"2024-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16176"}}