{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:12:55Z","timestamp":1789186375209,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluates the clinical effects of a ketogenic diet (KD) versus a traditional comprehensive intervention, including lifestyle changes and oral contraceptives, in overweight or obese polycystic ovary syndrome (PCOS) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 70 overweight\/obese PCOS patients (body mass index [BMI] \u226524\u2009kg\/m<jats:sup>2<\/jats:sup>) treated between December 2022 and December 2023 was conducted. The patients were categorized into two groups based on their past treatment modality: Group 1 received a KD treatment (<jats:italic>N<\/jats:italic>\u2009=\u200935), and Group 2 underwent comprehensive intervention (<jats:italic>N<\/jats:italic>\u2009=\u200935), with both treatments lasting 3\u2009months. Changes in body weight, BMI, sex hormone levels, glucose\u2010lipid metabolism indicators, and liver and kidney function were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups experienced significant reductions in body weight and BMI after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), with the KD group showing a greater reduction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). luteinizing hormone (LH), LH\/follicle\u2010stimulating hormone (FSH), and total testosterone (TT) levels decreased significantly in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The KD treatment led to significant reductions in fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA\u2010IR), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), while the comprehensive intervention resulted in decreased FBG and ALT, and increased high\u2010density lipoprotein\u2010cholesterol (HDL\u2010c) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, the KD group had a greater reduction in FBG, and showed decreases in TG and AST, which remained unchanged in the comprehensive intervention group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The short\u2010term KD treatment provides significant weight loss and effectively improves hormone regulation and glucose\u2010lipid metabolism in overweight or obese PCOS patients, offering a valuable therapeutic option for managing the condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16178","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:19:22Z","timestamp":1733962762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of short\u2010term ketogenic diet on sex hormones and glucose\u2010lipid metabolism in overweight or obese patients with polycystic ovary syndrome"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1774-2022","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology, Fuxing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fuxing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fuxing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Fuxing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15245069"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179558119874042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad463"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14913"},{"issue":"7","key":"e_1_2_10_6_1","article-title":"Efficacy of very low\u2010calorie ketogenic diet with the Pronokal\u00ae method in obese women with polycystic ovary syndrome: a 16\u2010week randomized controlled trial","volume":"12","author":"Pandurevic S","year":"2023","journal-title":"EndocrConnect"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26462"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13704"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00831-w"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234998"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuad152"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02277-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14650"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-024-00556-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_10_16_1","first-page":"1","article-title":"Department of Disease Control Ministry of health PRC. 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