{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:57:44Z","timestamp":1765961864196,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to assess the impacts of various trigger day progesterone (P<jats:sub>4<\/jats:sub>) and luteinizing hormone (LH) levels on live birth rates (LBRs) in fresh in vitro fertilization (IVF) cycles, considering their elevation from stimulation and premature luteinization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included the first ovarian stimulation cycles with GnRH antagonist protocol of 1253 patients who underwent intracytoplasmic sperm injection and fresh embryo transfer at a tertiary clinic's IVF center between 2010 and 2016. Participants were divided into four groups based on trigger day serum P<jats:sub>4<\/jats:sub> and LH levels, using the 90th percentile thresholds for P<jats:sub>4<\/jats:sub> (1.7\u2009ng\/mL) and LH (5.2\u2009IU\/L). The primary outcome measure was LBR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LBRs observed in the respective groups were as follows: P<jats:sub>4<\/jats:sub>\u2009&lt;\u20091.7\u2009ng\/mL and LH &lt;5.2\u2009IU\/L (21.3%, 214\/1005); P<jats:sub>4<\/jats:sub>\u2009&lt;\u20091.7\u2009ng\/mL and LH \u22655.2\u2009IU\/L (19.1%, 22\/115); P<jats:sub>4<\/jats:sub>\u2009\u2265\u20091.7\u2009ng\/mL and LH &lt;5.2\u2009IU\/L (19.3%, 23\/119); and P<jats:sub>4<\/jats:sub>\u2009\u2265\u20091.7\u2009ng\/mL and LH \u22655.2\u2009IU\/L (28.6%, 4\/14). There were no statistically significant differences between the groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.782). Additionally, a multivariate generalized additive model, adjusted for female age, body mass index, infertility duration, number of embryos transferred, and embryo transfer day, found that the interaction between LH and P<jats:sub>4<\/jats:sub> levels did not significantly predict LBRs (<jats:italic>p<\/jats:italic>\u2009=\u20090.533). However, univariate analysis identified an optimal trigger day P<jats:sub>4<\/jats:sub> range between 0.58 and 1.69\u2009ng\/mL for achieving higher LBRs, demonstrating a non\u2010linear relationship. Furthermore, total FSH and LH dosages during stimulation had a statistically significant combined effect on trigger day P<jats:sub>4<\/jats:sub> levels (<jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.001), with the addition of LH leading to lower P<jats:sub>4<\/jats:sub> levels compared to cycles stimulated with recombinant FSH alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relationship and interaction between trigger day LH and P<jats:sub>4<\/jats:sub> levels do not significantly influence LBRs, as variations in LH do not alter the effect of P<jats:sub>4<\/jats:sub>, suggesting that the impact of P<jats:sub>4<\/jats:sub> elevation on LBRs is independent of its cause, whether from ovarian stimulation or premature luteinization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16181","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T01:16:06Z","timestamp":1736212566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of the trigger day progesterone, luteinizing hormone and their interaction on live birth rates in <scp>GnRH<\/scp> antagonist cycles"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-8956","authenticated-orcid":false,"given":"Onur","family":"Ince","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hacettepe University, Faculty of Medicine  Ankara Turkey"},{"name":"Department of Statistics Middle East Technical University, Faculty of Arts and Science  Ankara Turkey"},{"name":"Department of Obstetrics and Gynecology Health Sciences University, Tepecik Education and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-2253","authenticated-orcid":false,"given":"Bulent","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Health Sciences University, Tepecik Education and Research Hospital  Izmir Turkey"},{"name":"Department of Obstetrics and Gynecology Recep Tayyip Erdogan University, Faculty of Medicine  Rize Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)39309-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.722655"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.06.042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.ijem_331_21"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00067"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy082"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03323-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2010.00749.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2018-043"},{"key":"e_1_2_7_12_1","first-page":"76","volume-title":"Sensitivity 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