{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:44:53Z","timestamp":1788921893504,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib\/pembrolizumab (LEN\/PEM). The utility of certain inflammatory biomarkers in endometrial liquid\u2010based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil\u2010to\u2010lymphocyte ratio (NLR) were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN\/PEM between August 2018 and March 2024. Predictors for overall response (OR), disease control, and progression\u2010free survival, based on neutrophil\/lymphocyte counts, NLR scores of the endometrial LBC prior to initial treatment, and peripheral blood prior to initial treatment and prior to LEM\/PEM treatment were compared using a receiver operating characteristic curve. Significant predictors were evaluated using the log\u2010rank test, and multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although neutrophil counts and NLR score in endometrial LBC prior to initial treatment were better effective predictors for OR, the most accurate predictor of a progression\u2010free status was NLR score in peripheral blood prior to LEM\/PEM (0.722, 95% CI: 0.45\u20130.99, sensitivity: 57.1%, specificity: 94.4%). In peripheral blood prior to LEN\/PEM, the lower NLR (NLR &lt;5.39) group had a significantly longer PFS than the higher NLR (5.39\u2009\u2264\u2009NLR) group (<jats:italic>p<\/jats:italic>\u2009=\u20090.023, median survival: 13.5 vs. 3.0\u2009months), and tended to be independently correlated with PFS (hazard ratio\u2009=\u20092.571; 95% CI\u2009=\u20090.857\u20137.719; <jats:italic>p<\/jats:italic>\u2009=\u20090.092).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inflammatory biomarkers in endometrial LBC failed to predict the efficacy of LEN\/PEM, while peripheral blood NLR score sampled prior to LEN\/PEM potentially could be a significant predictor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16182","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T08:20:36Z","timestamp":1734942036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A potential 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Kozai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-1624","authenticated-orcid":false,"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University hospital  Kagoshima Japan"},{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-2189","authenticated-orcid":false,"given":"Hiroaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"},{"name":"Course of Advanced Cancer Medicine for Gynecologic Cancer Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima 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