{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:37:57Z","timestamp":1753879077292,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate if maternal serum soluble fms\u2010like tyrosine kinase\u20101(sFlt\u20101) to placental growth factor (PlGF) ratio levels at term can anticipate the following adverse pregnancy outcomes: small for gestational age neonates; operative delivery for suspected fetal welfare compromise; and neonatal compromise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of a single hospital database containing antenatal soluble fms\u2010like tyrosine kinase\u20101 to placental growth factor (sFlt\u20101\/PlGF) ratio results together with associated demographic, clinical and investigative information. Subjects with antenatal sFlt\u20101\/PlGF measurements taken \u226537\u2009weeks' gestation were analyzed. sFlt\u20101\/PlGF ratio cut\u2010offs of &lt;38, 38\u2013110, 111\u2013201 and &gt;201 were tested against the following outcomes: birthweight \u226410th and \u22643rd centiles; operative delivery for suspected fetal welfare compromise; 5\u2009min Apgar score; and neonatal admissions for extra care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant associations were found between sFlt\u20101\/PlGF ratios 111\u2013201 and birthweights \u226410th centile (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, odds ratio [OR] 3.04, 95% confidence interval [CI] 1.52\u20136.10), and between operative delivery for suspected fetal welfare compromise and sFlt\u20101\/PlGF ratios 111\u2013201 (<jats:italic>p<\/jats:italic>\u2009=\u20090.04, OR 2.21, 95% CI 1.03\u20134.75) and &gt;201 (<jats:italic>p<\/jats:italic>\u2009=\u20090.01, OR 4.73, 95% CI 1.45\u201315.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicates that maternal serum sFlt\u20101\/PlGF ratios performed at term may subsequently help identify significantly small\u2010for\u2010gestational age fetuses and operative delivery for suspected fetal welfare compromise. Further prospective studies may confirm these findings and substantiate the clinical importance of sFlt\u20101\/PlGF measurements in assisting the management of pregnancies at term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16191","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T03:19:43Z","timestamp":1735874383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can maternal serum soluble fms\u2010like tyrosine kinase\u20101 to placental growth factor levels at term anticipate adverse pregnancy outcomes?"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8215-5650","authenticated-orcid":false,"given":"Sarah A.","family":"Corker","sequence":"first","affiliation":[{"name":"Melbourne Medical School, University of Melbourne  Parkville Victoria Australia"},{"name":"Pregnancy Research Centre, Department of Maternal Fetal Medicine the Royal Women's Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Cade","sequence":"additional","affiliation":[{"name":"Pregnancy Research Centre, Department of Maternal Fetal Medicine the Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun P.","family":"Brennecke","sequence":"additional","affiliation":[{"name":"Pregnancy Research Centre, Department of Maternal Fetal Medicine the Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56906-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1590459"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.766694"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2017.1334800"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853127"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.03.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.6.1540"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-021-06186-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-019-09694-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414838"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.10.909"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14799"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100394"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.12.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15146"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.09.009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499580"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13978"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18894"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.07.245"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50676"},{"key":"e_1_2_9_24_1","unstructured":"RobsonSC MartinW MorrisRK.Green\u2013top guideline on the investigation and management of the small\u2013for\u2013gestational\u2013age fetus. 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