{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:35:58Z","timestamp":1790631358191,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29\u2010year\u2010old gravida 2 para 2 woman presented with abnormal genital bleeding 6\u2009months after delivery. Endometrial histology suggested PSTT. Serum human chorionic gonadotropin (hCG) was 117\u2009mIU\/mL and serum estradiol (E2) were 51\u2009pg\/mL. She reported increased appetite, sweating, fatigue, and 7\u2010kg weight loss within 3\u2009months. Blood samples showed a thyroid\u2010stimulating hormone (TSH) level &lt;0.01\u2009\u03bcIU\/mL, FT3: 24.3\u2009pg\/mL, FT4: 5.3\u2009ng\/mL. The patient was diagnosed with hyperthyroidism. After thyroid function normalized, laparoscopic hysterectomy and bilateral salpingectomy were performed. Two years postsurgery, there was no recurrence, and thyroid function improved. The hCG produced from gestational trophoblastic disease has stronger TSH activity than that from gestational trophoblasts. However, in PSTT, the E2 level, which increases thyroid\u2010binding proteins and suppresses elevated thyroid hormone levels, is low and may induce hyperthyroidism. In cases of suspected PSTT, thyroid function should be evaluated when hyperthyroid symptoms are present.<\/jats:p>","DOI":"10.1111\/jog.16193","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T05:41:19Z","timestamp":1735191679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of transient hyperthyroidism induced by placental site trophoblastic tumor"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7317-1959","authenticated-orcid":false,"given":"Sumire","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-6688","authenticated-orcid":false,"given":"Takashi","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8569-1872","authenticated-orcid":false,"given":"Harumi","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-164X","authenticated-orcid":false,"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University  Bunky\u014d Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"issue":"11","key":"e_1_2_9_2_1","article-title":"Report of the Japanese Society of Gynecologic Oncology","volume":"74","year":"2022","journal-title":"Acta Obstet Gynaecol Jpn"},{"issue":"12","key":"e_1_2_9_3_1","article-title":"Report of the Japanese Society of Gynecologic 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