{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:37:23Z","timestamp":1753879043662,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medroxyprogesterone acetate (MPA) is a promising fertility\u2010sparing treatment for early stage endometrial cancer; however, it has a high recurrence rate and is inferior to surgery. Although the site of recurrence is mostly the endometrium, we here report a case of metastatic recurrence to the para\u2010aortic lymph node with endometrial recurrence despite a careful follow\u2010up. A 31\u2010year\u2010old woman was diagnosed with grade 1 endometrioid carcinoma, stage IA without myometrial invasion. She requested fertility\u2010sparing treatment and underwent a 48\u2010week MPA therapy with complete remission. Follow\u2010up continued with ultrasonography and endometrial biopsy every 3 and 6\u2009months, respectively; however, at 10\u2009months following MPA therapy, cancer recurrence was detected in the endometrium and para\u2010aortic lymph node, requiring hysterectomy, bilateral adnexectomy, and lymph node dissection, followed by paclitaxel\/carboplatin chemotherapy. This case report highlights that lymph node recurrence can develop despite careful follow\u2010up following complete remission with MPA therapy for stage IA endometrial cancer.<\/jats:p>","DOI":"10.1111\/jog.16217","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T06:31:21Z","timestamp":1737527481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial cancer with para\u2010aortic lymph node metastasis following medroxyprogesterone acetate therapy: A case report"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7119-2296","authenticated-orcid":false,"given":"Miku","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-1205","authenticated-orcid":false,"given":"Yoshifumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-5570","authenticated-orcid":false,"given":"Yuji","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.08.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15767"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8344"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.06.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.602"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3417-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.16038"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001164"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0587-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.09.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.09.015"},{"key":"e_1_2_9_13_1","unstructured":"Uterine neoplasms version 3.2024. NCCN Clinical Practice Guidelines in Oncology (NCCN guideline). 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