{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:40Z","timestamp":1753878460664,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016170","name":"Japan Blood Products Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study is to clarify the frequencies of fresh frozen plasma (FFP)\u2009\u00b1\u2009fibrinogen concentrate administration (fibrinogen concentrate [FC] therapy) and antithrombin (AT) concentrate administration (AT therapy) for the women with obstetrical disseminated intravascular coagulation (DIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two retrospective multicenter case\u2013control studies as Study\u20101 (January\u2013December 2018) and Study\u20102 (July 2022\u2013June 2023) were conducted. Study\u20101 was the historical control of Study\u20102. All participants experienced a blood loss of \u22651000\u2009mL during vaginal delivery or \u22652000\u2009mL during cesarean section. All participants were subsequently assigned to the DIC group or non\u2010DIC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study\u20101 comprised 175 women (obstetrical DIC, 27; control, 148; by the previous criteria) and Study\u20102 comprised 175 women (obstetrical DIC, 9; control, 166; by the new criteria). The frequencies of FFP (\u00b1FC therapy) or FC therapy in DIC group were significantly higher than non\u2010DIC group in Study\u20101 (88.9% vs. 25.0%, 44.4% vs. 4.0%) and Study\u20102 (100% vs. 24.7%, 77.8% vs. 5.4%); however, the frequencies of AT therapy were similar. Furthermore, in the DIC group, all women with fibrinogen &lt;150\u2009mg\/dL received FFP\u2009\u00b1\u2009FC therapy in Study\u20101 (<jats:italic>n<\/jats:italic>\u2009=\u200919) and Study\u20102 (<jats:italic>n<\/jats:italic>\u2009=\u20098); however, those with AT activity &lt;70% received AT therapy (16.7% [4\/24] and 12.5% [1\/8], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We revealed an association between the high frequency of FFP\u2009\u00b1\u2009FC therapy and lower fibrinogen levels, but a low frequency of AT therapy regardless of AT activity, in obstetrical DIC regardless of diagnosis criteria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16220","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:58:21Z","timestamp":1738195101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fresh frozen plasma, fibrinogen concentrate, and antithrombin concentrate administration for obstetrical disseminated intravascular coagulation by the Japanese previous and new criteria"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-5422","authenticated-orcid":false,"given":"Mamoru","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kansai Medical University  Hirakata Osaka Japan"},{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2592-9951","authenticated-orcid":false,"given":"Shigetaka","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Center for Maternal, Fetal, and Neonatal Medicine, Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-361X","authenticated-orcid":false,"given":"Shintaro","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Urayasu Hospital  Urayasu Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aiiku Maternal and Child Health Center, Aiiku Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7525","authenticated-orcid":false,"given":"Hironobu","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-164X","authenticated-orcid":false,"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Graduate School of Medicine  Tokyo 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