{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:14:19Z","timestamp":1777029259421,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We reviewed case reports of acute fatty liver of pregnancy (AFLP) in Japan and summarized its characteristics, including coagulation factors, fibrinolytic factors, and platelet counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed\/Medline and Ichushi databases from 2000 to 2022 were used to survey articles related to AFLP, and 93 articles (102 patients) were ultimately identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The characteristics of the coagulation and fibrinolysis systems in AFLP were as follows: the prothrombin time\u2010international normalized ratio and activated partial prothrombin time were prolonged (median value [quartiles]: 1.59 [1.31, 2.02] and 47.5\u2009s [28.2, 97.5], respectively), and antithrombin and alpha 2\u2010antiplasmin levels were low (23.0% [17.0, 33.0] and 44.6%, respectively), indicating non\u2010productive coagulopathy due to severe liver damage. The concentrations of the thrombin\u2010antithrombin complex and fibrinogen\/fibrin degradation products were high (60.0\u2009ng\/mL [49.1, 82.8] and 49.2\u2009\u03bcg\/mL [20.8, 143.7], respectively), while the level of fibrinogen was low (82.0\u2009mg\/dL [52.5, 153.5]), suggesting disseminated intravascular coagulation with increased coagulation activity. A platelet count \u226512\u2009\u00d7\u200910<jats:sup>4<\/jats:sup>\/\u03bcL was detected in approximately 70% of AFLP cases, and the median was within the normal range (16.1\u2009\u00d7\u200910<jats:sup>4<\/jats:sup>\/\u03bcL [11.1, 19.2]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coagulopathy changes in AFLP may be based on non\u2010productive coagulopathy of coagulation and fibrinolytic factors as well as disseminated intravascular coagulation with mild or no thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16230","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:55:36Z","timestamp":1740016536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute fatty liver of pregnancy may be associated with non\u2010productive coagulopathy of coagulation and fibrinolytic factors as well as disseminated intravascular coagulation with mild or no thrombocytopenia: Review of case reports in Japan"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5187-2368","authenticated-orcid":false,"given":"Hirotada","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-1572","authenticated-orcid":false,"given":"Akihide","family":"Ohkuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Tochigi 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