{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:39:03Z","timestamp":1782470343120,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Tissue factor pathway inhibitor 2 (TFPI2) is a preoperative biomarker that was developed to discriminate ovarian benign tumors from cancer and is covered by health insurance in Japan. The purpose of this study was to evaluate how the TFPI2 changes after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum levels of TFPI2 (cut off 191\u2009pg\/mL) and CA125 (cut off 35\u2009U\/mL) before and after primary debulking surgery in patients with ovarian malignant tumors were evaluated among recurrent and nonrecurrent cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 46 cases were analyzed, including 11 borderline tumors, 13 clear cell carcinomas, 15 serous carcinomas, 4 endometrioid carcinomas, and 3 mucinous carcinomas. Among 37 patients without recurrence, the preoperative mean levels of TFPI2 (235.3\u2009pg\/mL, range: 78.3\u2013607.7) and CA125 (1125.5\u2009U\/mL, range: 6.2\u20136272.0) were higher than the cutoff values. The mean minimum level of TFPI2 decreased to below the cutoff (150.2\u2009pg\/mL, range 56.4\u2013471.1) at 3\u2009months or more after primary debulking surgeries. The postoperative TFPI2 level exceeded the cutoff in 11 out of 37 patients without recurrence (29.7%); however, the postoperative TFPI2 level decreased in 8 patients. The mean maximum levels of TFPI2 and CA125 in 9 patients after recurrence were 492.6\u2009pg\/mL and 727.4\u2009U\/mL, respectively. Moreover, the mean TFPI2 level was higher than the preoperative one (421.5\u2009pg\/mL), different from CA125 (2903.8\u2009U\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest the clinical validity of TFPI2 as a serum tumor marker for postoperative recurrence screening among malignant ovarian tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16241","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:59:31Z","timestamp":1740016771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of tissue factor pathway inhibitor 2 (<scp>TFPI2<\/scp>) as a novel serum marker for malignant tumors of the ovary before and after treatment: A case\u2010control study"],"prefix":"10.1111","volume":"51","author":[{"given":"Yuki","family":"Ogawara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho Ruiz","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-5329","authenticated-orcid":false,"given":"Yuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Division of Medical Safety Science National Institute of Health Sciences  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Faculty of Health Data Science Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-6269","authenticated-orcid":false,"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"},{"name":"Department of Gynecology and Reproductive Medicine Ms. Clinic MayOne  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Healthcare Information Management The University of Tokyo Hospital  Tokyo Japan"},{"name":"Yokohama City University School of Data Science  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-4227","authenticated-orcid":false,"given":"Fuminori","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-4717","authenticated-orcid":false,"given":"Taichi","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama Rosai Hospital  Yokohama Japan"},{"name":"Clinical Laboratory Department Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-0844","authenticated-orcid":false,"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092230"},{"key":"e_1_2_9_3_1","unstructured":"Cancer Information Service National Cancer Center Japan (Vital Statistics of Japan Ministry of Health Labour and Welfare) [cited 2023 Dec 1].Cancer statistics. Available fromhttps:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/index.html"},{"key":"e_1_2_9_4_1","unstructured":"Japan Society of Obstetrics and Gynecology.Annual report of Gynecologic Oncology Committee [cited 2024 Aug 22].2020Available fromhttps:\/\/www.jsog.or.jp\/activity\/pdf\/2020_nenpou.pdf"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0084"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.06.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12071050"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08061-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111721"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515583076"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124648"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400282j"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165609"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-021-01914-y"},{"key":"e_1_2_9_16_1","unstructured":"The attached document for TFPI2 [cited 2024 Feb 12]. Available from:https:\/\/www.info.pmda.go.jp\/tgo\/pack\/30200EZX00040000_A_01_02\/"},{"key":"e_1_2_9_17_1","article-title":"Blood biomarkers for the non\u2010invasive diagnosis of endometriosis","volume":"5","author":"Nisenblat V","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260440027017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006101200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605406"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524804"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:52:38Z","timestamp":1741744358000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jog.16241"],"URL":"https:\/\/doi.org\/10.1111\/jog.16241","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16241"}}