{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:11:57Z","timestamp":1778695917763,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abdominal pregnancy (AP) is a rare form of ectopic pregnancy. It is associated with significant maternal and fetal risks, including high rates of morbidity and mortality. The condition poses considerable therapeutic challenges, particularly in the mid to late stages of gestation. To date, there is no standardized treatment protocol for such cases. We describe a case of a 37\u2010year\u2010old woman, G2P1, who was diagnosed with a live 16\u2010week AP. The patient underwent multidisciplinary treatment, including ultrasound\u2010guided methotrexate injection into the fetal heart, lauromacrogol injection into the placenta, oral administration of mifepristone, and subsequent laparotomy to remove the fetus, placenta, and left fallopian tube. This approach successfully demised the fetus, reduced the placental blood supply, and created more favorable conditions for surgery. The patient recovered uneventfully post\u2010surgery. This case illustrates the potential benefits of a combined therapeutic approach in successfully managing mid\u2010term AP.<\/jats:p>","DOI":"10.1111\/jog.16277","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T23:35:32Z","timestamp":1742772932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of mid\u2010term abdominal pregnancy: A rare case report and literature review"],"prefix":"10.1111","volume":"51","author":[{"given":"Junlei","family":"Lu","sequence":"first","affiliation":[{"name":"The Fourth Clinical School of Medicine Zhejiang Chinese Medical University  Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkai","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University  Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-8946","authenticated-orcid":false,"given":"Jing","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University  Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.fertnstert.2023.07.014","article-title":"Nontubal ectopic pregnancies: overview of diagnosis and treatment","volume":"120","author":"Sokalska A","year":"2023","journal-title":"Fertil Steril"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejogrb.2020.05.067","article-title":"Ultrasound\u2010guided intrasacular injection of methotrexate in the management of ectopic pregnancies with embryo. A 12\u2010year experience report in a tertiary hospital","volume":"251","author":"Alvarez\u2010Sarrado L","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/uog.17384","article-title":"Treatment of cervical pregnancy with ultrasound\u2010guided local methotrexate injection","volume":"50","author":"Yamaguchi M","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jmig.2015.04.008","article-title":"Local methotrexate injection as the first\u2010line treatment for cesarean scar pregnancy: review of the literature","volume":"22","author":"Cheung VY","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"issue":"7","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.7863\/jum.2003.22.7.709","article-title":"Minimally invasive management of 14.5\u2010week abdominal pregnancy without laparotomy: a novel approach using percutaneous sonographically guided feticide and systemic methotrexate","volume":"22","author":"Mitra AG","year":"2003","journal-title":"J Ultrasound Med"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00404-018-4743-3","article-title":"Advanced abdominal pregnancy: a search for consensus. Review of literature along with case report","volume":"298","author":"Rohilla M","year":"2018","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13104-016-1844-6","article-title":"A case report of an asymptomatic late term abdominal pregnancy with a live birth at 41\u2009weeks of gestation","volume":"9","author":"Nassali MN","year":"2016","journal-title":"BMC Res Notes"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"297.e1","DOI":"10.1016\/j.ajog.2007.09.044","article-title":"Advanced extrauterine pregnancy: diagnostic and therapeutic challenges","volume":"198","author":"Worley KC","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.crad.2005.10.013","article-title":"The value of magnetic resonance imaging in the diagnosis and management of extra\u2010uterine abdominal pregnancy","volume":"61","author":"Lockhat F","year":"2006","journal-title":"Clin Radiol"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12884-023-05793-1","article-title":"A delayed spontaneous second\u2010trimester tubo\u2010abdominal pregnancy diagnosed and managed by laparotomy in a \u201cself\u2010identified\u201d infertile woman, a case report and literature review","volume":"23","author":"Zhang Y","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"issue":"5","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"CS53","DOI":"10.12659\/MSM.881752","article-title":"Successful operative management of an intact second trimester abdominal pregnancy with additional preoperative selective catheter embolization and postoperative methotrexate therapy","volume":"17","author":"Demendi C","year":"2011","journal-title":"Med Sci Monit"},{"issue":"5","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/01.AOG.0000127946.14387.48","article-title":"Minimally invasive management of an advanced abdominal pregnancy","volume":"103","author":"Rahaman J","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"6","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/00042728-200506000-00004","article-title":"Microvascular embolization following polidocanol microfoam sclerosant administration","volume":"31","author":"Eckmann DM","year":"2005","journal-title":"Dermatologic Surg"},{"issue":"1","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12884-023-05455-2","article-title":"Comparison of clinical safety and efficacy of ultrasound\u2010guided local lauromacrogol injection versus uterine artery embolization in the treatment of caesarean scar pregnancy: a systematic review and meta\u2010analysis","volume":"23","author":"Du Z","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"3269","article-title":"The efficacy of mifepristone combined with methotrexate for the treatment of ectopic pregnancy: a systematic review and meta\u2010analysis","volume":"54","author":"Su Q","year":"2022","journal-title":"Ann Med"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T11:14:08Z","timestamp":1743333248000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jog.16277"],"URL":"https:\/\/doi.org\/10.1111\/jog.16277","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16277"}}