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At present, ADCs are divided into tumors as HPV\u2010associated ADCs (HA\u2010ADCs) and HPV\u2010independent ADCs (HI\u2010ADCs), including adenocarcinomas in situ (AIS) as their precursor, both of which consist of variable histological types. The usual\u2010type accounts for the majority of HA\u2010ADCs, and the gastric\u2010type is a representative of HI\u2010ADCs. Notably, it is clinicopathologically significant to differentiate between HA\u2010ADCs and HI\u2010ADCs because of the discrepancy in prognosis between them. Although relatively rare in comparison with HPV\u2010associated AIS (HA\u2010AIS), HPV\u2010independent AIS (HI\u2010AIS) has gradually attracted attention since gastric\u2010type ADC (g\u2010ADC) was introduced in the World Health Organization Classification 4th ed. (2014). Occasional HA\u2010ADCs and HI\u2010ADCs, including HA\u2010AIS and HI\u2010AIS, require p16 immunostaining, in situ hybridization, or HPV testing to differentiate between them because morphological features alone cannot often be conclusive for the diagnosis. A system focusing on the infiltrative pattern has been introduced due to its clinicopathological value. Staging criteria of HA\u2010ADCs with polypoid\/exophytic growth, recommended by the International Collaboration on Cancer Reporting, may supplement the International Federation of Gynecology and Obstetrics staging system for clinical management and treatment.<\/jats:p>","DOI":"10.1111\/jog.16287","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T02:15:05Z","timestamp":1745288105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histological classification of uterine cervical adenocarcinomas: Its alteration and current status"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-360X","authenticated-orcid":false,"given":"Masanori","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Miyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-838X","authenticated-orcid":false,"given":"Mitsutake","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-0609","authenticated-orcid":false,"given":"Akira","family":"Yabuno","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000909"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000741"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.16168"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14724"},{"key":"e_1_2_10_7_1","volume-title":"WHO classification of Tumours. 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