{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:34:20Z","timestamp":1753878860196,"version":"3.41.2"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Preeclampsia (PE) is a frequent and dangerous multisystemic pregnancy complication, associated with blood pressure control. Some antioxidants, including chocolate\u2010derived epicatechin, can effectively attenuate hypertensive disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess whether epicatechin or dark chocolate (DC) could revert vascular increased reactivity and oxidative stress, both features of an experimental PE model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats from healthy pregnant or PE groups received vehicle, epicatechin (10\u2009mg\/kg\/day) po, or DC (1\u2009g) po, administered on days 1\u201314 (early) or days 7\u201321(late) of pregnancy. Blood pressure was measured by the tail\u2010cuff plethysmography method. Aorta contractility was evaluated using a conventional isolated organ bath, and oxidative stress was determined by nicotine adenine dinucleotide phosphate reduced (NADPH)\u00a0serum activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Epicatechin and DC significantly reduced hypertension, decreased abdominal aorta contractility, and decreased NADPH activity of the PE animals. The effects were more evident when administered during the last 2\u2009weeks of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest that epicatechin has a significant antihypertensive effect in <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> mediated by an antioxidant activity that improves vascular contractility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16290","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T23:51:39Z","timestamp":1747093899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epicatechin prevents preeclampsia\u2010associated hypertension and oxidative stress"],"prefix":"10.1111","volume":"51","author":[{"given":"Luis J","family":"Soto","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"del Tufi\u00f1o","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha E","family":"Macias\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seidy","family":"Castro\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefan\u00eda","family":"Jim\u00e9nez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-1363","authenticated-orcid":false,"given":"Rosa A","family":"Bobadilla\u2010Lugo","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina IPN  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313276"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S204017441900014X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.099861"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113055"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.09.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179545X17752325"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2021.01.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107928"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b802662a"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225243"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510168103"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900602"},{"issue":"11","key":"e_1_2_9_16_1","first-page":"84","article-title":"Materiales de cacao de inter\u00e9s farmacol\u00f3gico (Theobroma cacao L.)","author":"B\u00e1ez OL","year":"2016","journal-title":"Espac ID Innov M\u00e1s Desarro"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(93)90159-U"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00273-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.05.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000133734.32125.c7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.05.022"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.4.1018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.110101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.3328"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.015"},{"issue":"1","key":"e_1_2_9_26_1","first-page":"40","article-title":"Subrenal aortic coarctation: characterization as a pregnancy\u2010induced hypertension model in the rat","volume":"49","author":"L\u00f3pez\u2010S\u00e1nchez P","year":"2006","journal-title":"Proc West Pharmacol Soc"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3697"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321810500403722"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2017.05.011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000105"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1356"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051496"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666181015151350"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950701252827"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184320"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200526150113"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181fe62e3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh163"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200111002-00002"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030484"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.01.003"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-41"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488877"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy130"},{"key":"e_1_2_9_47_1","first-page":"37","article-title":"Segmental aortic differences in vascular responses during pregnancy","volume":"39","author":"Bobadilla R","year":"1996","journal-title":"Proc West Pharmacol Soc"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01283.2006"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0260-8"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058200.90059.B1"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180100301"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.01.009"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2022.06.007"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106127"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13510"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108001"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21596"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108807"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5782485"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2020.1754850"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030467"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2024.104263"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T23:29:18Z","timestamp":1748215758000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jog.16290"],"URL":"https:\/\/doi.org\/10.1111\/jog.16290","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16290"}}