{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:36:46Z","timestamp":1753879006823,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0064\/2020","UIDB\/04750\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020","UIDB\/04750\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Multiple primary cancers are relevant outcomes among survivors of gynecological cancers, contributing to the overall cancer burden and having a potential impact on the management of each primary cancer. This study aimed to estimate the risk and survival of third primary cancers (TPCs) among females with a cervical, endometrial, or ovarian first primary cancer (FPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a cervical, endometrial, or ovarian FPC from the Portuguese North Region Cancer Registry, diagnosed between 2000 and 2010 (<jats:italic>n<\/jats:italic>\u2009=\u20095846), were followed for a TPC (December 31, 2015) and death from any cause (December 31, 2023). The cumulative incidence of TPCs and mortality was estimated. Patients with a TPC were matched (1:1) to patients without a TPC (FPC\u2009+\u2009second primary cancer [SPC] only) to compare survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 29 (0.5% of FPCs and 5.4% of SPCs) TPCs were diagnosed. The most common sites were digestive organs (<jats:italic>n<\/jats:italic>\u2009=\u20099) followed by breast and urinary tract cancers (<jats:italic>n<\/jats:italic>\u2009=\u20094 each). Among all FPCs, the 10\u2010year cumulative incidence (95% confidence interval [CI]) of a TPC was 0.5% (0.3%\u20130.7%) and among SPCs, it was 5.8% (3.3%\u20138.2%). For TPCs, compared to matched patients, the age\u2010adjusted hazard ratio (95% CI) for death was 3.0 (1.39\u20136.50). The 10\u2010year cumulative mortality of TPCs and matched patients was 75.7% and 42.0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Northern Portugal, TPCs occurred mainly in digestive organs, followed by the breast and urinary tract, with a 10\u2010year cumulative incidence of 0.5% among all FPCs. TPCs had a worse long\u2010term survival compared to patients with an SPC only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16297","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:50:17Z","timestamp":1745988617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk and survival of third primary cancers in a population\u2010based cohort of patients with a cervical, endometrial, or ovarian cancer"],"prefix":"10.1111","volume":"51","author":[{"given":"Elisabete","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto Universidade do Porto  Porto Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica Faculdade de Medicina da Universidade do Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica Faculdade de Medicina da Universidade do Porto  Porto Portugal"},{"name":"Grupo de Abordagem de Les\u00f5es Precursoras e Cancro Precoce \u2010 Centro de Investiga\u00e7\u00e3o (CI\u2010IPOP) &amp; 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