{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:53:29Z","timestamp":1784433209228,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["CMU\u20102567"],"award-info":[{"award-number":["CMU\u20102567"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemoglobin (Hb) Adana, the alpha\u2010globin gene mutation at codon 59 (GGC\u2009\u2192\u2009GAC), is very rare globally but occasionally encountered in Southeast Asia. Its combination with alpha0\u2010thalassemia (\u2013<jats:sup>SEA<\/jats:sup>) results in Hb H\u2010Adana, which can lead to severe fetal anemia. This report describes a 22\u2010year\u2010old woman at 33\u2009weeks, presenting with fetal cardiomegaly with early hydropic changes and anemia (middle cerebral artery peak systolic velocity: 1.75\u2009multiple of median [MoM]). Cordocentesis revealed a Hb level of 4.3\u2009g\/dL, and intrauterine transfusion (IUT) was performed. However, non\u2010reassuring fetal heart rate developed after IUT and cesarean section was performed. A preterm live male infant was delivered, weighing 1455\u2009g, and was confirmed to be Hb H\u2010Adana. Post\u2010natal life was transfusion\u2010dependent. In conclusion, this case focuses on prenatal features of fetal Hb H\u2010Adana, which caused fetal anemia and hydrops fetalis in the third trimester. In cases of unexplained fetal anemia, Hb H\u2010Adana should be listed in the differential diagnoses, especially in areas of high prevalence.<\/jats:p>","DOI":"10.1111\/jog.16310","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T23:24:49Z","timestamp":1746573889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal diagnosis and management of fetal anemia caused by hemoglobin H\u2010Adana: A case report"],"prefix":"10.1111","volume":"51","author":[{"given":"Sirinart","family":"Sirilert","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasemsri","family":"Srisupundit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimlak","family":"Charoenkwan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Chiang Mai University  Chiang Mai Thailand"},{"name":"Thalassemia and Hematology Center Faculty of Medicine, Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunee","family":"Phusua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Chiang Mai University  Chiang Mai Thailand"},{"name":"Thalassemia and Hematology Center Faculty of Medicine, Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-6478","authenticated-orcid":false,"given":"Theera","family":"Tongsong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57353"},{"key":"e_1_2_8_3_1","first-page":"207","article-title":"\u03b1\u2010Thalassemia with haemoglobin Adana mutation: prenatal diagnosis","volume":"36","author":"Zainal NZ","year":"2014","journal-title":"Malays J Pathol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0059-9_4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2010.493405"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2017.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03080.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2014.916720"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528510"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0397-7"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T23:29:40Z","timestamp":1748215780000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jog.16310"],"URL":"https:\/\/doi.org\/10.1111\/jog.16310","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16310"}}