{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:37:20Z","timestamp":1789133840286,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the effect of esketamine on perioperative anxiety and depressive symptoms, acute stress reaction, and serum neurotransmitters in patients undergoing total hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 120 patients undergoing total hysterectomy from May 2020 to June 2021 were retrospectively analyzed and divided into group C (3\u2009mL of saline administered intravenously 10\u2009min before surgical excision, 65 patients) or group K (0.5\u2009mg\/kg of esketamine administered intravenously 10\u2009min before surgical excision, 55 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute stress reaction, depression, and anxiety; and myeloperoxidase levels were lower while serum dopamine, 5\u2010hydroxytryptamine, neuropeptide, as well as brain\u2010derived neurotrophic factor levels were higher in group K than those in group C at 12\u2009h postoperatively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, analgesic effect and postoperative fatigue at 3\u2009h and 12\u2009h postoperatively were lower in group K than those in group C (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The incidence of adverse reactions in group K (14.55%) did not differ significantly from group C (4.62%) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, as a preventive measure for patients undergoing total hysterectomy, esketamine can reduce perioperative anxiety and depression, result in good analgesic and sedative effects without significantly increasing adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16311","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T23:10:47Z","timestamp":1746745847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of esketamine on perioperative anxiety and depressive symptoms in patients undergoing total hysterectomy"],"prefix":"10.1111","volume":"51","author":[{"given":"Jinfeng","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7653-9010","authenticated-orcid":false,"given":"Donghang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","article-title":"Surgical approach to hysterectomy for benign gynaecological disease","volume":"2015","author":"Aarts JW","year":"2015","journal-title":"Cochrane Database Syst 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