{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:26:39Z","timestamp":1771460799193,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to investigate the association between placental insufficiency and complications in extremely preterm infants in the context of ischemic placental disease (IPD), including preeclampsia, small\u2010for\u2010gestational\u2010age (SGA), and placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants born between 22 and 28\u2009weeks of gestation were classified into IPD and non\u2010IPD groups, matched 1:1 by gestational age and sex. The incidence of neonatal complications was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis included 48 infants in each group. The IPD group had a significantly lower birth weight (IPD vs. non\u2010IPD: 679\u2009g vs. 979\u2009g, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas the non\u2010IPD group was characterized by a higher prevalence of spontaneous preterm births (12% vs. 79%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a significantly higher incidence of histological chorioamnionitis (CAM) (15% vs. 50%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The IPD group showed a significantly higher incidence of bronchopulmonary dysplasia (BPD) compared to the non\u2010IPD group (85% vs. 48%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with no significant differences in other complications such as intraventricular hemorrhage, retinopathy of prematurity, and necrotizing enterocolitis. Logistic regression identified IPD as a significant risk factor for BPD (odds ratio [OR] [95% confidence interval]: 9.4 [2.8\u201331.8], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), along with preeclampsia (OR: 4.9 [1.3\u201318.3], <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and SGA (OR: 31.9 [5.9\u2013171], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CAM was not associated with BPD (OR: 0.6 [0.2\u20131.7], <jats:italic>p<\/jats:italic>\u2009=\u20090.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placental insufficiency, manifesting as IPD, is strongly associated with an increased risk of BPD in extremely preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16315","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T23:55:27Z","timestamp":1747094127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ischemic placental disease as a risk factor for bronchopulmonary dysplasia in extremely preterm infants"],"prefix":"10.1111","volume":"51","author":[{"given":"Yu","family":"Ariyoshi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine The University of Tokyo  Tokyo 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