{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:38:04Z","timestamp":1760661484616,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Progesterone has to be administered to prepare the endometrium for frozen\u2013thawed blastocyst transfer (FBT) in a hormone replacement cycle (HRC). The objective of this study was to investigate the efficacy and safety of using Crinone\u00ae progesterone gel alone in HRC\u2010FBT.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this multicenter prospective study, HRC\u2010FBT was performed with blastocysts with a Gardner's classification of 3BB or better, and application of 90\u2009mg\/day of vaginal gel (Crinone, Merck BioPharma, Tokyo) was started when the endometrial thickness reached 8\u2009mm or more. The primary endpoint was the clinical pregnancy rate (CPR). Safety endpoints included genital bleeding and other adverse events. Recruitment started in May 2018.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 181 patients were enrolled, and 156 were included in the efficacy analysis. The overall CPR was 41.7% (65\/156). In patients younger than 38\u2009years (n<\/jats:italic>\u2009=\u2009113), the CPR was 48.7% (55\/113), and in those aged 38\u2009years or older (n<\/jats:italic>\u2009=\u200943), it was 23.3% (10\/43). The overall CPR was comparable to that observed in the Japan Society of Obstetrics and Gynecology ART2020 National Survey, which reported a pregnancy rate of 36.3% in frozen embryo transfer cycles. Adverse events such as light genital bleeding occurred before and after pregnancy in some patients, but at a low frequency (<10%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Use of Crinone progesterone vaginal gel alone is adequate in HRC\u2010FBT and is not associated with any safety issues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16325","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:20:16Z","timestamp":1748913616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter cohort study of the effect of Crinone\u00ae progesterone vaginal gel alone to prepare the endometrium for frozen\u2013thawed blastocyst transfer in a hormone replacement cycle"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-1054","authenticated-orcid":false,"given":"Akiko","family":"Takashima","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Toho University Medical Center Sakura Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Shibui","sequence":"additional","affiliation":[{"name":"Cinema Art Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Hamatani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Nishitan ART clinic Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-4063","authenticated-orcid":false,"given":"Yoshimitsu","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-4227","authenticated-orcid":false,"given":"Fuminori","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shiga University of Medical Science Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine Sugiyama Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Toho University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"The Medical Information Center, Kyushu University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Toho University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12009"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"e12552","article-title":"Assisted reproductive technology in Japan: a summary report for 2021 by the ethics Committee of the Japan Society of obstetrics and gynecology. Reprod","volume":"23","author":"Katagiri Y","year":"2023","journal-title":"Med Biol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12494"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(14)50063-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90181-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54178-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60214-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133027"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"11","article-title":"Study of the influence of serum progesterone levels on the pregnancy rate of frozen\u2010thawed early embryo transfer with vaginal Utrogestan treatment","volume":"33","author":"Henmi H","year":"2016","journal-title":"J Fertil Implant"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00010-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.067"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:31:31Z","timestamp":1760646691000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jog.16325"],"URL":"https:\/\/doi.org\/10.1111\/jog.16325","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16325"}}