{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:39:11Z","timestamp":1760661551227,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and toxicity of consolidation chemotherapy (C\u2010CT) following concurrent cisplatin chemotherapy combined with intensity\u2010modulated radiotherapy (IMRT) in patients with early\u2010stage cervical cancer who present high\u2010risk factors (HRFs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2013 and 2023, a total of 190 women were included in this retrospective study. Among these, 82 patients received postoperative concurrent chemoradiotherapy (CCRT) with weekly cisplatin and IMRT (45.0\u201350.4\u2009Gy), followed by C\u2010CT, while 108 patients received CCRT alone. A propensity score matching (PSM) was performed with a ratio of 1:1. Clinical parameters, overall survival (OS), and relapse\u2010free survival (RFS) were analyzed for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up duration was 50.2\u2009months. The 4\u2010year OS rates were 88.7% in the C\u2010CT group and 87.9% in the CCRT\u2010only group (<jats:italic>p<\/jats:italic>\u2009=\u20090.886). The 4\u2010year RFS rates were 76.3% for the C\u2010CT group and 80.5% for the CCRT\u2010only group (<jats:italic>p<\/jats:italic>\u2009=\u20090.289). In patients with three or more positive lymph nodes, C\u2010CT was associated with significantly improved OS compared to the CCRT\u2010only group (HR 0.14, 95% CI 0.02\u20130.88, <jats:italic>p<\/jats:italic>\u2009=\u20090.036), while RFS showed no significant difference (HR 0.80, 95% CI 0.27\u20132.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.676). However, the incidence of grade 3\/4 hematologic toxicity was higher in the C\u2010CT group (16.8% vs. 1.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study found that C\u2010CT following concurrent cisplatin chemotherapy with IMRT did not confer additional benefits over CCRT alone in the majority of early\u2010stage cervical cancer patients with HRFs, except in those with three or more positive lymph nodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16346","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:29:21Z","timestamp":1750210161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent cisplatin chemotherapy with intensity\u2010modulated radiotherapy followed by consolidation chemotherapy in early\u2010stage cervical cancer patients with high\u2010risk factors after radical hysterectomy"],"prefix":"10.1111","volume":"51","author":[{"given":"Si\u2010Tong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-2886","authenticated-orcid":false,"given":"Gui\u2010Fen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Zhongshan Hospital, Fudan University  Shanghai 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