{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:03:21Z","timestamp":1773680601218,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of dolutegravir (DTG) on obstetrical outcomes for women living with HIV (WLWH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study evaluated adult WLWH in antenatal care between 2016 and 2022 at two Nigerian centers. Patients were stratified into three antiretroviral therapy (ART) exposure groups: non\u2010DTG ART, DTG\u2010switch, and DTG. Multivariate linear and logistic regression models were utilized to assess the association between the type of ART and gestational weight gain (GWG), small for gestational age (SGA), gestational hypertension, and preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 1839 (77.1%) non\u2010DTG users, 359 (15%) DTG users, and 188 (7.9%) DTG switchers. The adjusted association between DTG exposure and GWG was 0.72 (\u22120.08, 1.53) kg and 0.51 (\u22120.51, 1.54) kg for the DTG and DTG\u2010switch groups, respectively, compared to other ARTs. The adjusted odds ratios for gestational hypertension were 0.47 (0.09, 2.49) and 1.31 (0.43, 4.02), 0.57 (0.22, 1.52) and 0.73 (0.25, 2.10) for preterm birth, and 0.55 (0.25, 1.20) and 0.26 (0.08, 0.83) for SGA in DTG and DTG\u2010switch, respectively, compared to other ARTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DTG therapy is not associated with the risk of gestational hypertension nor preterm birth, and antenatal ART switching to DTG decreases the risk of growth restriction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.16349","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:45:19Z","timestamp":1750646719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of dolutegravir on obstetrical outcomes among women living with <scp>HIV<\/scp>: A retrospective cohort study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-4688","authenticated-orcid":false,"given":"Ammar","family":"Al Naimi","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Obstetrics and Gynecology Buergerhospital  Frankfurt Germany"},{"name":"Department of Obstetrics and Perinatal Medicine Goethe University Hospital of Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Rawizza","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseun","family":"Olaifa","sequence":"additional","affiliation":[{"name":"APIN Public Health Initiatives  Abuja Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olabanjo","family":"Ogunsola","sequence":"additional","affiliation":[{"name":"APIN Public Health Initiatives  Abuja Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prosper","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"APIN Public Health Initiatives  Abuja Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-4572","authenticated-orcid":false,"given":"Phyllis","family":"Kanki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13120"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-022-00608-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2200600"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00173-4"},{"key":"e_1_2_9_7_1","unstructured":"Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission. Recommendations for the Use of Antiretroviral Drugs During Pregnancy and Interventions to Reduce Perinatal HIV Transmission in the United States. 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