{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:24Z","timestamp":1787320824286,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the incidence of the peripheral cysts sign of ovarian thecoma\u2010fibroma groups (OTFGs), and to discuss the value of the peripheral cysts sign in the diagnosis of OTFGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 112 patients with surgically proven fibromas and fibrothecomas were screened consecutively from January 2016 to December 2022. Peripheral cysts were recognized in 25 patients (Group A) but were absent in the remaining 87 patients (Group B). Clinical data (including age, menopausal state, incidence of vaginal bleeding, and thickening of the endometrium) were recorded and compared between the two groups. Preoperative images of Group A and 50 matched patients with other ovarian solid and cystic tumors were combined (test group, 75 patients) and reviewed by two radiologists before and after learning about the sign. The diagnostic accuracy of OTFGs with peripheral cysts was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperative imaging revealed that 22.3% (25\/112) of patients with OTFGs presented with peripheral cysts. Age (56.4\u2009\u00b1\u200915.1\u2009years vs. 43.3\u2009\u00b1\u200916.2\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), postmenopausal status (84% vs. 48%,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.002), and presence of thickening of the endometrium (39% vs. 7%,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.001) were significantly different between Groups A and B. The diagnostic accuracy of OTFGs was significantly improved after learning about the sign [radiologist 1, 16% (4\/25) vs. 84% (21\/25),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; radiologist 2, 32% (8\/25) vs. 88% (22\/25),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of peripheral cysts was not uncommon in patients with OTFGs, especially in postmenopausal patients. Familiarity with the sign could help avoid misdiagnosing solid and cystic\u2010like ovarian OTFGs as other ovarian solid and cystic tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.16369","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T21:24:36Z","timestamp":1751577876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The peripheral cysts sign of ovarian thecoma\u2010fibroma groups: Incidence and diagnostic value"],"prefix":"10.1111","volume":"51","author":[{"given":"Shulin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Guangdong Second Provincial General Hospital  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The Eighth Affiliated Hospital, Sun Yat\u2010Sen University  Shen Zhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"},{"name":"Department of Radiology The Sixth Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruling","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Science Research Department, CT &amp; MR Business Division Canon Medical Systems (China)  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology The Eighth Affiliated Hospital, Sun Yat\u2010Sen University  Shen Zhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-0346","authenticated-orcid":false,"given":"Jian","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.053"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091679"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(90)90009-A"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.12.025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-00989-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.3.9280262"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210157"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.204371"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-016-0291-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7221"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.04.010"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199309000-00017"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"29","article-title":"Contribution of ultrasound in the study of ovarian fibrothecomas: a series of 47 cases","volume":"95","author":"Slimani O","year":"2017","journal-title":"Tunis Med"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20130634"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.758036"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.24si045501"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.304095745"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.1.2052725"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02172-3"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.16369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T01:43:48Z","timestamp":1763603028000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.16369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jog.16369"],"URL":"https:\/\/doi.org\/10.1111\/jog.16369","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16369"}}