{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:11:11Z","timestamp":1789161071530,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515110116"],"award-info":[{"award-number":["2020A1515110116"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Whether hepatitis C virus (HCV) infection is associated with the risk of gestational diabetes mellitus (GDM) remains controversial. This study aims to systematically evaluate the impact of HCV infection on GDM risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seven electronic databases, including PubMed, Embase, Web of Science, Ovid, ScienceDirect, China National Knowledge Infrastructure, and SinoMed, were retrieved for all related studies by October of 2024. Studies on the relationship between HCV infection and GDM risk were included. The quality of included studies was assessed using the Newcastle\u2010Ottawa Scale. A random effects meta\u2010analysis was performed to estimate the overall odds ratio (OR) and 95% confidence intervals (CI) by Stata software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 18 studies comprising 45\u2009567\u2009678 pregnancies. HCV infection was significantly associated with increased GDM risk (pooled OR\u2009=\u20091.21, 95% CI: 1.04\u20131.40), with substantial heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200987.6%). Subgroup analyses demonstrated significant associations in European populations (OR\u2009=\u20091.66, 95% CI: 1.13\u20132.43;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200940.4%), prospective cohort studies (OR\u2009=\u20091.72, 95% CI: 1.33\u20132.22;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%), human immunodeficiency virus\u2010positive populations (OR\u2009=\u20092.04, 95% CI: 1.04\u20133.99;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200946.2%), and general populations (OR\u2009=\u20091.16, 95% CI: 1.00\u20131.34;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200988.7%). There was a positive but not statistically significant association for the North America population and retrospective studies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with considerable heterogeneity. The overall results were robust, indicated by sensitivity analysis, and no obvious publication bias was observed according to Begg's test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HCV infection is positively associated with increased GDM risk. Further studies with diverse representative populations and more rigorous prospective designs are warranted to establish more comprehensive conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70015","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T03:04:01Z","timestamp":1753931041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of hepatitis C virus infection with risk of gestational diabetes mellitus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"Qingyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Prevention and Health Care Southern University of Science and Technology Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Center, The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Prevention and Health Care Southern University of Science and Technology Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6474-360X","authenticated-orcid":false,"given":"Shanshan","family":"Wei","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Center, The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01320-X"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Hepatitis C. 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