{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:09:44Z","timestamp":1782439784047,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the correlation between patient age and long\u2010term re\u2010intervention requirements for symptomatic uterine fibroids through stratified age\u2010group analysis following ultrasound\u2010guided high\u2010intensity focused ultrasound (UsgHIFU) ablation therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study evaluated 443 uterine fibroids from the Liuzhou Maternal and Child Healthcare Hospital (2018\u20132020). Post\u2010ablation re\u2010intervention trajectories were monitored over 36\u2009months following UsgHIFU. Age\u2010stratified analyses included analysis of variance for continuous parameters and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests for categorical variables. Nonlinear dynamics were modeled using multivariable adaptive regression splines, with threshold regression identifying clinically significant transition points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 443 patients who underwent UsgHIFU, 35 (7.9%) required re\u2010intervention within 36 postoperative months. Adjusted odds ratio (OR) analysis revealed distinct age\u2010dependent patterns. For patients below the 39\u2010year threshold, each additional year demonstrated a positive association with re\u2010intervention risk (OR\u2009=\u20091.20, 95% confidence interval [CI] 1.05\u20131.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0079). Conversely, in patients aged \u226539\u2009years, each additional year showed a statistically significant negative association with re\u2010intervention (OR\u2009=\u20090.70, 95% CI 0.56\u20130.87;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with uterine fibroids undergoing UsgHIFU, the correlation between age and the risk of re\u2010intervention after treatment follows an inverted U\u2010shaped curve. Both older and younger age groups are associated with a reduced risk of re\u2010intervention. UsgHIFU is a noninvasive and effective method for treating uterine fibroids. Patients who undergo UsgHIFU treatment experience a low re\u2010intervention rate, with younger patients or those closer to menopause achieving better treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70045","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T06:18:48Z","timestamp":1756966728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The association between age and re\u2010intervention rates in uterine fibroid patients after\n                    <scp>UsgHIFU<\/scp>\n                    therapy: A cohort study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8694-7181","authenticated-orcid":false,"given":"Lin","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering Chongqing Medical University  Chongqing 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in Medicine and Engineering, College of Biomedical Engineering Chongqing Medical University  Chongqing China"},{"name":"Department of Gynecology GuangZhou Women and Children's Medical Center LiuZhou Hospital  Liuzhou Guangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering Chongqing Medical University  Chongqing China"},{"name":"Department of Gynecology GuangZhou Women and Children's Medical Center LiuZhou Hospital  Liuzhou Guangxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering Chongqing Medical University  Chongqing China"},{"name":"School of Public Health Chongqing 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