{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:50:40Z","timestamp":1778161840318,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti\u2010inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (\n p<\/jats:italic>\n \u2009<\u20090.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70055","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T23:04:39Z","timestamp":1756163079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of boric acid on ovarian damage caused by endotoxaemia"],"prefix":"10.1111","volume":"51","author":[{"given":"Melek","family":"Aydin","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Kirsehir Ahi Evran University Kirsehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-2322","authenticated-orcid":false,"given":"Nebahat","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Kirsehir Ahi Evran University Kirsehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Kirsehir Ahi Evran University Kirsehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Kirsehir Ahi Evran University Kirsehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"733","volume-title":"Large animal internal medicine","author":"Mackay R","year":"1996"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"100","article-title":"Sepsis","volume":"21","author":"F\u0131\u015fg\u0131n NT","year":"2004","journal-title":"OMU Med J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00432-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.1999.01511.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01376.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010181"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241500750008484"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00816-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20198595"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052281"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2010.01.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1545-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-023-03699-9"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"133","article-title":"Experimental models in sepsis","volume":"5","author":"Iskit AB","year":"2005","journal-title":"J Intensive Care Med"},{"key":"e_1_2_9_16_1","volume-title":"Endotext [Internet]","author":"Feingold KR","year":"2000"},{"key":"e_1_2_9_17_1","unstructured":"Ayranc\u0131DFE.Histopathological Changes Observed on Testis Liver Kidney and Brain Tissues in Rats Applied with Acute Boric Acid. [Doctoral Thesis]. Eski\u015fehir: Eski\u015fehir Osmangazi University.2005."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2406594"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.6.867"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802555577"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.08.005"},{"key":"e_1_2_9_23_1","unstructured":"SezerA Memi\u015fD UstaU S\u00fctN.The effect of dexmetomidine on liver histopathology in a rat sepsis model: an experimental pilot study.2010;16:108\u2013112."},{"issue":"3","key":"e_1_2_9_24_1","first-page":"172","article-title":"Potential protective effect of boron against gentamicin\u2010induced oxidative stress on rat tissues","volume":"10","author":"K\u00fc\u00e7\u00fckkurt \u0130","year":"2017","journal-title":"Kocatepe Vet J"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T01:38:55Z","timestamp":1763602735000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jog.70055"],"URL":"https:\/\/doi.org\/10.1111\/jog.70055","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70055"}}