{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:44:07Z","timestamp":1773211447223,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Abnormal uterine bleeding (AUB) is a common clinical challenge faced by women, often indicating underlying gynecological disorders, including endometrial pathologies. The evaluation of apoptotic biomarkers has gained attention as a potential method to elucidate the mechanisms driving these pathologies. AUB lacks precise diagnostic tools, with an insufficient understanding of apoptotic biomarkers' roles in endometrial changes, hindering effective management and targeted therapies for affected women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The objectives are to identify apoptotic biomarkers associated with endometrial histopathological changes, evaluate their diagnostic potential for abnormal uterine bleeding, and enhance understanding of underlying biological mechanisms in affected women. Analyzing healthcare data reveals patterns that inform clinical decisions and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Content\u2010based filtering technique combined with deep feedforward neural networks can uncover patterns in biomarkers, forecast histopathological outcomes, improve diagnostic accuracy, and tailor treatment strategies for women experiencing abnormal uterine bleeding. Findings show that in cycles under 21\u2009days, 5% of patients experienced bleeding for 4\u2009days, while 74% had 4\u20136\u2009days of bleeding, and 21% bled for more than 6\u2009days. This result was implemented using Python software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Future research could explore targeted therapies based on apoptotic biomarkers, enhancing diagnostic accuracy and personalized treatment strategies for women with abnormal uterine bleeding and associated endometrial histopathological changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70059","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T05:54:43Z","timestamp":1757051683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating apoptotic biomarkers with endometrial histopathological changes in women with abnormal uterine bleeding"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-8051","authenticated-orcid":false,"given":"Bellala Venkata","family":"Madhavi","sequence":"first","affiliation":[{"name":"Department of Pathology Maharaja\u2019s Institute of Medical Sciences  Vizianagaram Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thallury Shirin","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Pathology GITAM Institute of Medical Sciences and Research  Visakhapatnam Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bellala Ravi","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Omega Hospital  Visakhapatnam Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathipaty Josephine","family":"Bindu","sequence":"additional","affiliation":[{"name":"Department of Pathology NRI Institute of Medical Sciences  Visakhapatnam Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"AhmedRet al.Role of apoptotic proteins in endometrial dysfunction associated with abnormal uterine bleeding.2022;67(1):45\u201352."},{"issue":"1","key":"e_1_2_8_3_1","first-page":"73","article-title":"Caspase activation and its role in endometrial pathology in women with AUB","volume":"42","author":"Barnes H","year":"2023","journal-title":"Int J Gynecol Pathol"},{"key":"e_1_2_8_4_1","first-page":"37","article-title":"Pro\u2010apoptotic and anti\u2010apoptotic protein imbalance in endometrial tissues: implications for AUB","volume":"88","author":"Davison R","year":"2022","journal-title":"Clin Biochem"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"1124","article-title":"Bcl\u20102 family proteins in endometrial pathologies: correlations with histopathological changes","volume":"30","author":"Hassan M","year":"2023","journal-title":"Reprod Sci"},{"key":"e_1_2_8_6_1","first-page":"391","article-title":"Cytokine profiles and their association with apoptotic activity in endometrial biopsies of AUB patients","volume":"16","author":"Iqbal S","year":"2023","journal-title":"J Inflamm Res"},{"key":"e_1_2_8_7_1","first-page":"101","article-title":"Histological evaluation of endometrial changes in relation to apoptotic signalling in AUB","volume":"45","author":"Kaur G","year":"2023","journal-title":"Gynecol Oncol Rep"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"113","article-title":"p53 pathway alterations in endometrial tissues of women with AUB","volume":"238","author":"Nguyen T","year":"2023","journal-title":"J Cell Physiol"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"550","article-title":"Apoptotic mechanisms in endometrial cancer development in the context of AUB","volume":"54","author":"O'Reilly 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