{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:45:40Z","timestamp":1773211540015,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n This study aimed to assess fetal cardiac function in response to epilepsy and antiepileptic drugs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This cross\u2010sectional prospective study included 31 pregnant women with epilepsy (22 on monotherapy, 9 unmedicated) and 45 randomly selected, gestational age\u2010matched low\u2010risk pregnant women. The mean gestational ages were comparable across groups: 30.27\u2009\u00b1\u20092.95\u2009weeks for the monotherapy group, 30.11\u2009\u00b1\u20092.80\u2009weeks for the unmedicated epilepsy group, and 31.13\u2009\u00b1\u20092.83\u2009weeks for the control group (\n p<\/jats:italic>\n \u2009=\u20090.397). Fetal cardiac function was evaluated using indices of systolic and diastolic function: isovolumetric contraction time, isovolumetric relaxation time (IRT), ejection time, myocardial performance index (MPI), mitral and tricuspid maximum early ventricular filling (\n E<\/jats:italic>\n ) wave velocity, maximum active atrial filling (\n A<\/jats:italic>\n ) wave velocity,\n E<\/jats:italic>\n \/\n A<\/jats:italic>\n ratios, mitral and tricuspid annular plane systolic excursion, and pulmonary and aortic artery peak velocities.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the monotherapy epilepsy group, IRT was significantly prolonged (47.77 vs. 42.78 vs. 43.47,\n p<\/jats:italic>\n \u2009=\u20090.006 and\n p<\/jats:italic>\n \u2009<\u20090.001), and MPI was significantly increased (0.49 vs. 0.46 vs. 0.46,\n p<\/jats:italic>\n \u2009=\u20090.027 and\n p<\/jats:italic>\n \u2009=\u20090.194) compared to the unmedicated epilepsy and control groups. Tricuspid valve\n E<\/jats:italic>\n values were significantly lower in the monotherapy epilepsy group (40.49 vs. 43.87,\n p<\/jats:italic>\n \u2009=\u20090.034). Furthermore, IRT values were prolonged in the subgroup with seizures during pregnancy compared to those without (40.73 vs. 44.45,\n p<\/jats:italic>\n \u2009=\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n To our knowledge, this was the first study to examine the potential cardiac functional impact of epilepsy and antiepileptic drugs. This study demonstrated a small but significant association between maternal antiepileptic drug use and impaired fetal cardiac diastolic function, as assessed by ultrasound.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70060","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:50:24Z","timestamp":1756903824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of epilepsy and antiepileptic drugs on fetal cardiac functions: A cross\u2010sectional study from a tertiary center"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-8053","authenticated-orcid":false,"given":"G\u00f6ksun","family":"\u0130pek","sequence":"first","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Turkish Ministry of Health Ankara City Hospital Ankara 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