{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:04Z","timestamp":1787015644044,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Preterm delivery (PTD) is a leading cause of neonatal morbidity and mortality. Accurate prediction is crucial for optimizing clinical outcomes, particularly in women with a short cervix. Although fetal fibronectin (FFN) is widely used to predict PTD, placental alpha\u2010microglobulin\u20101 (PAMG\u20101) has gained attention for its potential to improve predictive accuracy. This study aimed to evaluate the utility of quantitative PAMG\u20101 assessment for predicting impending PTD in asymptomatic women with a short cervix (\u226425\u2009mm) between 24 and 34\u2009weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational cohort study analyzed 212 cervicovaginal fluid samples from 77 patients (132 from 49 singleton and 80 from 28 twin pregnancies). PAMG\u20101 and FFN levels were measured, and multivariate logistic regression was performed to evaluate their association with PTD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In singleton pregnancies, positive PAMG\u20101 was independently associated with impending PTD, with odds ratios of 7.84 (95% confidence interval [CI], 2.02\u201330.50;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and 7.34 (95% CI, 2.75\u201319.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for PTD within 1 and 2\u2009weeks, respectively. Quantitative PAMG\u20101 showed a dose\u2010dependent relationship, with PTD risks increasing from 4.3% (&lt;1000\u2009pg\/mL) to 50.0% (\u22653000\u2009pg\/mL) within 1\u2009week and from 10.0% to 90.0% for PTD within 2\u2009weeks. In twin pregnancies, both PAMG\u20101 and FFN showed limited predictive utility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the potential of PAMG\u20101 quantification as a valuable tool for refining PTD risk stratification, particularly in singleton pregnancies. While further prospective multicenter validation is needed, these findings provide new clinical insights for improving PTD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70071","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T06:54:47Z","timestamp":1757141687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative assessment of placental alpha macroglobulin\u20101 for predicting impending preterm delivery in asymptomatic women with a short cervix"],"prefix":"10.1111","volume":"51","author":[{"given":"Yuki","family":"Nozaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya 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